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Spatiotemporal Control of Protein Activity through Optogenetic Allosteric Regulation
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Ancestral Protein-Based Lighting.

Stephanie Willeit1, Alexander Mauz1, David Gutiérrez-Armayor1

  • 1Technical University of Munich, Campus Straubing for Biotechnology and Sustainability, Chair of Biogenic Functional Materials, Schulgasse 22, 94315, Straubing, Germany.

Advanced Materials (Deerfield Beach, Fla.)
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PubMed
Summary
This summary is machine-generated.

Researchers designed ancestral-like fluorescent proteins (FPs) using ancestral sequence reconstruction. These novel FPs enhance stability and performance in bio-hybrid light-emitting diodes (Bio-HLEDs), paving the way for sustainable optoelectronics.

Keywords:
ancestral sequence reconstructionbio‐hybrid light‐emitting diodesfluorescent proteinphoton manipulationprotein‐lighting

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Area of Science:

  • Protein engineering
  • Optoelectronics
  • Biotechnology

Background:

  • Protein-optoelectronics offers sustainable technology but faces challenges in maintaining protein activity in non-native environments.
  • Modern fluorescent proteins (FPs) are crucial for bio-hybrid light-emitting diodes (Bio-HLEDs).

Purpose of the Study:

  • To identify and design ancestral-like fluorescent proteins (FPs) for improved performance and stability in optoelectronic devices.
  • To explore ancestral sequence reconstruction (ASR) as a method for protein design in sustainable technologies.

Main Methods:

  • Ancestral sequence reconstruction (ASR) applied to a dataset of 221 modern FPs.
  • Computational design and bacterial production of a common ancestral FP.
  • Fabrication and testing of red-emitting Bio-HLEDs utilizing the designed FP.

Main Results:

  • A computationally designed ancestral-like FP, named QuetzalFP, was identified.
  • QuetzalFP exhibits high photoluminescence quantum yields (90% green, 80% red) and tendency to agglomerate in polymer coatings.
  • Red-emitting Bio-HLEDs with QuetzalFP showed approximately twofold enhanced stability compared to references.

Conclusions:

  • ASR is an effective strategy for designing functional proteins for optoelectronics.
  • QuetzalFP serves as a promising platform for protein engineering in sustainable lighting applications.
  • The developed ancestral-like FPs enhance the stability and performance of Bio-HLEDs.