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Related Concept Videos

Autism Spectrum Disorder01:19

Autism Spectrum Disorder

357
Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by persistent deficits in social communication and interaction alongside restrictive and repetitive behaviors or interests. ASD is sometimes accompanied by intellectual impairment.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
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Related Experiment Video

Updated: Sep 18, 2025

Testing Sensory and Multisensory Function in Children with Autism Spectrum Disorder
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Atypical Scene-Selectivity in the Retrosplenial Complex in Individuals With Autism Spectrum Disorder.

Andrew S Persichetti1, Taylor L Li1, W Dale Stevens2

  • 1Section on Cognitive Neuropsychology, Laboratory of Brain and Cognition, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA.

Autism Research : Official Journal of the International Society for Autism Research
|June 25, 2025
PubMed
Summary
This summary is machine-generated.

Individuals with autism spectrum disorder (ASD) show weaker scene-selectivity in the retrosplenial complex (RSC), impacting memory-guided navigation. This difference was not observed in the occipital place area (OPA).

Keywords:
autism spectrum disorderfunctional MRInavigationscene perceptionspatial cognition

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Area of Science:

  • Neuroscience
  • Cognitive Science
  • Developmental Psychology

Background:

  • Individuals with autism spectrum disorder (ASD) often exhibit navigation impairments, particularly in memory-guided strategies.
  • Typically developing (TD) individuals show distinct neural systems for memory-guided (retrosplenial complex, RSC) and visually-guided (occipital place area, OPA) navigation.
  • Both RSC and OPA are characterized by scene-selectivity, responding more to places than faces or objects.

Purpose of the Study:

  • To investigate differences in scene-selectivity within the RSC and OPA between individuals with ASD and TD controls.
  • To determine if atypical scene-selectivity in these regions correlates with impaired memory-guided navigation in ASD.

Main Methods:

  • Functional magnetic resonance imaging (fMRI) was used to scan individuals with ASD and matched TD controls.
  • Participants viewed images of places and faces while performing a one-back task.
  • Scene-selectivity was measured by comparing brain responses to places versus faces.

Main Results:

  • Individuals with ASD exhibited significantly lower scene-selectivity in the RSC compared to TD individuals.
  • No significant difference in scene-selectivity was found in the OPA between the ASD and TD groups.
  • These findings suggest a potential neural basis for impaired memory-guided navigation in ASD.

Conclusions:

  • Atypical functioning in the RSC may contribute to difficulties with memory-guided navigation in individuals with ASD.
  • The OPA appears to function similarly in both ASD and TD groups regarding scene processing.
  • This study highlights specific neural differences related to spatial navigation in autism spectrum disorder.