Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Primary Lymphoid Organs01:16

Primary Lymphoid Organs

7.3K
Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
7.3K
Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

3.3K
All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
3.3K
The Tumor Microenvironment02:17

The Tumor Microenvironment

6.8K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Author Correction: Age-related epithelial defects limit thymic function and regeneration.

Nature immunology·2026
Same author

Resident phagocytes promote non-cell-autonomous fragmentation of apoptotic cells.

Science advances·2025
Same author

B cells targeting parasites capture spatially linked antigens to secure T cell help.

Science immunology·2025
Same author

Emergent BAX-mutated clonal hematopoiesis after venetoclax-based therapy for breast cancer.

Blood advances·2025
Same author

Proinflammatory cytokines sensitise mesenchymal stromal cells to apoptosis.

Cell death discovery·2025
Same author

Venetoclax dose escalation rapidly activates a BAFF/BCL-2 survival axis in chronic lymphocytic leukemia.

Blood·2024
Same journal

Diversity, Equality, and Inclusion in the naïve T Cell Receptor Repertoire.

Immunological reviews·2026
Same journal

Macrophage Plasticity and Immune Remodeling in Ischemic Heart Failure.

Immunological reviews·2026
Same journal

The T Cell Receptor: Molecular Sensor, Therapeutic Mediator and Probabilistic Driver of Adaptive Immunity.

Immunological reviews·2026
Same journal

Tissue-Resident Memory T Cells in the Heart: An Emerging Role in Chronic Inflammation.

Immunological reviews·2026
Same journal

Rethinking Immunity in Tissues: The Biology of Tertiary Lymphoid Structures.

Immunological reviews·2026
Same journal

Inflammation-Driven Lymphoid Structures: Organization, Function, and Clinical Impact Across Autoimmunity, Cancer, and Checkpoint Toxicity.

Immunological reviews·2026
See all related articles

Related Experiment Video

Updated: Sep 18, 2025

Author Spotlight: Advancing Thymic Epithelial Cells and T-Cell Research with Human Thymic Organoids
03:31

Author Spotlight: Advancing Thymic Epithelial Cells and T-Cell Research with Human Thymic Organoids

Published on: October 4, 2024

1.8K

Deconstructing the Thymic Microenvironment Through Genesis to Senescence.

Michael D'Andrea1,2, Kelin Zhao1,2, Daniel H D Gray1,2

  • 1The Walter and Eliza Hall Institute, Parkville, Victoria, Australia.

Immunological Reviews
|June 25, 2025
PubMed
Summary
This summary is machine-generated.

The thymus, crucial for adaptive immunity, relies on specialized thymic epithelial cells (TECs) to guide T-cell development and prevent autoimmunity. Advances in single-cell technologies reveal the thymus

Keywords:
T‐cell differentiationepitheliumsingle‐cell technologiesstromal cellsthymustolerance

More Related Videos

Isolation, Identification, and Purification of Murine Thymic Epithelial Cells
07:20

Isolation, Identification, and Purification of Murine Thymic Epithelial Cells

Published on: August 8, 2014

32.4K
Isolation and Transplantation of Different Aged Murine Thymic Grafts.
05:47

Isolation and Transplantation of Different Aged Murine Thymic Grafts.

Published on: May 13, 2015

14.1K

Related Experiment Videos

Last Updated: Sep 18, 2025

Author Spotlight: Advancing Thymic Epithelial Cells and T-Cell Research with Human Thymic Organoids
03:31

Author Spotlight: Advancing Thymic Epithelial Cells and T-Cell Research with Human Thymic Organoids

Published on: October 4, 2024

1.8K
Isolation, Identification, and Purification of Murine Thymic Epithelial Cells
07:20

Isolation, Identification, and Purification of Murine Thymic Epithelial Cells

Published on: August 8, 2014

32.4K
Isolation and Transplantation of Different Aged Murine Thymic Grafts.
05:47

Isolation and Transplantation of Different Aged Murine Thymic Grafts.

Published on: May 13, 2015

14.1K

Area of Science:

  • Immunology
  • Developmental Biology
  • Cell Biology

Background:

  • The thymus is central to adaptive immunity, guiding T-cell differentiation and establishing self-tolerance.
  • Thymic epithelial cells (TECs) create specialized microenvironments essential for T-cell development and preventing autoimmunity.
  • The thymic microenvironment undergoes significant changes throughout life, including development, injury, regeneration, and involution.

Purpose of the Study:

  • To review how scientific advancements, particularly technology, have shaped our understanding of the thymic microenvironment.
  • To highlight the cellular diversity within the thymus revealed by modern technologies.
  • To discuss the key processes shaping the thymic landscape, including progenitor differentiation and TEC specialization.

Main Methods:

  • Review of existing literature and technological advancements.
  • Focus on the impact of single-cell technologies.
  • Analysis of key cellular and molecular processes within the thymus.

Main Results:

  • Single-cell technologies have unveiled a highly diverse cellular landscape within the thymus.
  • Understanding of TEC specialization and distinct thymic microenvironments has significantly advanced.
  • Key developmental and regulatory processes, including AIRE function, are better characterized.

Conclusions:

  • The thymus harbors remarkable cellular diversity critical for T-cell development and immune tolerance.
  • Technological innovations, especially single-cell analysis, are revolutionizing thymic research.
  • Further exploration of the thymic microenvironment promises deeper insights into immunity and autoimmunity.