Molecular Epidemiology and Genetic Context of optrA-Carrying Linezolid-Resistant Enterococci from Humans and Animals in South Korea
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View abstract on PubMed
Summary
This summary is machine-generated.Linezolid resistance in Enterococcus is increasing, particularly with the spread of the optrA gene. Korean studies show this resistance in both humans and livestock, highlighting potential zoonotic spread and the need for global surveillance.
Area Of Science
- Antimicrobial resistance
- Molecular epidemiology
- One Health
Background
- Linezolid resistance in Enterococcus species is a growing public health concern.
- The transferable optrA gene contributes to linezolid resistance.
- Understanding the prevalence and spread of resistant strains is crucial.
Purpose Of The Study
- To evaluate linezolid resistance prevalence in South Korea.
- To characterize the molecular epidemiology of optrA-positive linezolid-resistant Enterococcus (LRE).
- To investigate the genetic contexts of LRE from clinical and animal sources.
Main Methods
- Nationwide surveillance of Enterococcus isolates from humans and livestock (2017-2019).
- Phenotypic susceptibility testing and optrA gene screening.
- Whole-genome sequencing for genetic context and phylogenetic analysis.
Main Results
- Linezolid resistance detected in clinical (0.2%) and livestock isolates (pigs 3.3%, cattle 4.3%, chickens 1.4%).
- optrA-positive LRE identified across all sources, with varying prevalence.
- ST476 strains showed genetic links to international isolates, suggesting global dissemination.
Conclusions
- Comprehensive assessment of linezolid resistance in South Korea.
- optrA-carrying ST476 lineages demonstrate zoonotic potential and international spread.
- Integrated One Health surveillance is essential to control transferable resistance genes.
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