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Updated: Sep 18, 2025

Synovial Fluid Analysis to Identify Osteoarthritis
Published on: October 20, 2022
Is Osteoarthritis a State of Joint Dysbiosis?
Mincong He1,2, Frank Kolhoff2,3, Michael A Mont4
1The Third Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou 510000, China.
Abstract:
Osteoarthritis (OA) has traditionally been defined as a degenerative joint disease driven by mechanical wear, aging, and metabolic disturbances. However, emerging evidence suggests that joint dysbiosis, a dysregulation in the joint microbiome, may play an important role in OA pathogenesis. This review explores the mechanisms linking dysbiosis to OA. We examine the presence and origin of joint dysbiosis, also highlighting the gut-joint and oral-joint axes as potential routes for microbial translocation. However, challenges remain in distinguishing causation from correlation and addressing microbial contaminants in microbiome studies. Future research should prioritize longitudinal studies and multiomics integration to elucidate the complex interplay between microbial communities and joint health.
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