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Related Experiment Video

Updated: Sep 18, 2025

Combination Radiotherapy in an Orthotopic Mouse Brain Tumor Model

Combination Radiotherapy in an Orthotopic Mouse Brain Tumor Model

Published on: March 6, 2012

Population-Based Real-World Outcomes of Post-Operative Adjuvant Brain Cavity Radiotherapy Versus Observation.

Zhang Hao Jim Li¹, Linden Lechner², Jennifer Wang²

¹Division of Radiation Oncology, Department of Surgery, University of British Columbia, Vancouver, BC V5Z 4E6, Canada.

Current Oncology (Toronto, Ont.)

|June 25, 2025

Summary

Post-operative stereotactic radiosurgery/fractionated radiotherapy (SRS/SFRT) significantly improves local control after brain metastasis resection compared to observation. En bloc resection and complete tumor removal are key factors for better local control.

Keywords:

CNS metastasis leptomeningeal disease palliative radiotherapy radionecrosis stereotactic radiosurgery stereotactic radiotherapy

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Last Updated: Sep 18, 2025

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Area of Science:

Neurosurgery
Radiation Oncology
Oncology

Background:

Brain metastases significantly impact patient outcomes.
Surgical resection is a common treatment modality.
Adjuvant therapies like stereotactic radiosurgery/fractionated radiotherapy (SRS/SFRT) are often considered post-resection.

Purpose of the Study:

To evaluate factors influencing outcomes in patients undergoing surgical resection of brain metastases.
To compare post-operative surveillance versus SRS/SFRT for brain metastases.
To identify predictors of local control after surgical resection.

Main Methods:

Retrospective multi-center chart review of 113 patients with brain metastases (2018-2020).
Exclusion of patients with prior whole-brain radiotherapy.
Analysis of local recurrence, intracranial control, radionecrosis, leptomeningeal disease, and overall survival using Kaplan-Meier and Cox proportional hazards models.

Main Results:

12-month local control was significantly higher with SRS/SFRT (69%) versus observation (31%) (p < 0.001).
No significant difference in 12-month distant intracranial control (44% vs 46%, p = 0.9) or overall survival (p = 0.6) was observed.
En bloc resection, resection without residual disease, and SRS/SFRT were predictive of local control on multivariable analysis.

Conclusions:

Post-operative SRS/SFRT improves local control for resected brain metastases, consistent with clinical trial data.
En bloc gross total resection should be prioritized to minimize local recurrence.
SRS/SFRT is a valuable adjuvant treatment option for selected patients.