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Updated: Sep 18, 2025
Dynamic Lung Tumor Tracking for Stereotactic Ablative Body Radiation Therapy
Published on: June 7, 2015
Design and Development of a Device (Sifilotto®) for Tumour Tracking in Cervical Cancer Patients Undergoing Robotic
Silvana Parisi1, Giacomo Ferrantelli1,2, Anna Santacaterina1,3
1Department of Biomedical Dental and Morphological and Functional Imaging (BIOMORF), Residency School of Radiation Oncology, University of Messina, Via Consolare Valeria 1, 98124 Messina, Italy.
Abstract:
Standard of Care (SOC) for locally advanced cervical cancer is represented by external beam radiation therapy concurrent with platinum-based chemotherapy and immunotherapy (cCIRT) followed by brachytherapy boost and immunotherapy maintenance. In some instances, it is impossible to perform brachytherapy due to patient and/or cancer issues. In these circumstances, an external beam boost could be delivered. Using a robotic arm LINAC, it is mandatory to use intramucosal implanted fiducials which are needed for tumour tracking. To avoid invasive procedures, we developed an original intravaginal 3D-printed universal device containing gold fiducials embedded within it. In this paper, we describe the step-by-step procedure that allowed us to obtain the utility model patent, including the in vivo test (feasibility, reproducibility, device compliance) on seven patients within the study protocol "STereotActic Radiotherapy Boost in locally Advanced Cervical carcinoma patientS" (STARBACS).
