Photoactivatable Aptamer-Based Biosensors for Point-of-Care Testing: Advances and Applications
Siyuan Wang1, Xinyun Cui2, Zixuan Zhong1
1State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Chemistry and Biomedicine Innovation Center (ChemBIC), Nanjing University, Nanjing 210023, China.
Biosensors
|June 25, 2025
Summary
Photoactivatable aptamers offer precise control for biosensors, enhancing point-of-care testing (POCT) sensitivity and selectivity. This technology is advancing medical diagnostics and environmental monitoring.
Area of Science:
- Biotechnology
- Analytical Chemistry
- Nanotechnology
Background:
- Photoactivatable aptamer sensing offers precise spatiotemporal control in detection.
- Optical response mechanisms enhance aptamer-based sensor regulation and target recognition.
Purpose of the Study:
- To review the design principles and regulation mechanisms of photoactivatable aptamers.
- To explore the application progress of photoactivatable aptamer biosensors in point-of-care testing (POCT).
- To discuss current challenges and future trends in this field.
Main Methods:
- Systematic review of literature on photoactivatable aptamer design and application.
- Analysis of optical response mechanisms in aptamer-based sensing.
- Evaluation of performance improvements in POCT systems.
Main Results:
- Photoactivatable aptamers enable enhanced selectivity, sensitivity, and dynamic response in biosensors.
- Integration into POCT platforms significantly improves diagnostic capabilities.
- The technology shows promise for precision medicine and environmental monitoring.
Conclusions:
- Photoactivatable aptamer biosensors are a powerful tool for advancing POCT.
- Continued development will lead to more sensitive, intelligent, and adaptable diagnostic tools.
- This technology supports innovations in precision medicine and environmental health.
