Advances of Nanozyme-Driven Multimodal Sensing Strategies in Point-of-Care Testing
Ziyi Chang1,2, Qingjie Fu2, Mengke Wang2
1Graduate School of Xinxiang Medical University, Xinxiang 453003, China.
Biosensors
|June 25, 2025
Summary
Nanozymes, novel enzyme mimics, offer rapid and efficient detection for point-of-care testing (POCT). This review explores their use in diagnostics, environmental monitoring, and food safety, addressing current challenges and future directions.
Area of Science:
- Biomaterials Science
- Analytical Chemistry
- Nanotechnology
Background:
- Point-of-care testing (POCT) is crucial for rapid medical diagnostics, improving healthcare efficiency.
- Nanozymes, enzyme-mimicking nanomaterials, offer advantages like high catalytic activity, stability, and low cost.
Purpose of the Study:
- To provide a comprehensive overview of nanozymes in POCT.
- To discuss various sensing strategies and applications of nanozymes in POCT.
- To identify challenges and future prospects for nanozyme-based POCT systems.
Main Methods:
- Systematic review of nanozyme characteristics and classifications.
- Analysis of sensing strategies: colorimetric, electrochemical, fluorescent, chemiluminescent, and SERS.
- Highlighting innovative designs for enhanced POCT sensitivity and accuracy.
Main Results:
- Nanozymes demonstrate significant potential across diverse POCT applications.
- Various sensing platforms effectively utilize nanozymes for sensitive detection.
- Innovative designs are improving the accuracy and scope of nanozyme-based POCT.
Conclusions:
- Nanozymes are promising for advancing POCT in diagnostics, environmental monitoring, and food safety.
- Addressing challenges in catalytic activity optimization, homogeneity, and scalability is key for practical implementation.
- Future research should focus on overcoming these limitations for widespread adoption of nanozyme-based POCT.
