Related Experiment Video
Updated: Sep 18, 2025
04:37
Comprehensive Analysis of Procoagulant Platelets Exhibiting Features of Necrosis, Apoptosis and Platelet Activation
Published on: May 23, 2025
639
Metabolic Reprogramming in Toll-like Receptor-Mediated Platelet Activation
Lih T Cheah1, Jawad S Khalil1, Mary McKay1
1Discovery and Translational Science Department, Leeds Institute of Cardiovascular & Metabolic Medicine, University of Leeds, Leeds LS2 9JT, UK.
Cells
|June 25, 2025
Summary
Platelets become highly glycolytic upon Toll-like receptor (TLR) activation, a process crucial for inflammation-driven aggregation. Targeting this metabolic shift offers a potential therapeutic strategy for TLR-initiated diseases.
Area of Science:
- Immunology
- Hematology
- Metabolic pathways
Background:
- Platelets play key roles beyond hemostasis, particularly in immunoinflammation.
- Toll-like receptors (TLRs) on platelets initiate immune and thrombotic responses.
- Current anti-platelet therapies risk bleeding, necessitating novel therapeutic targets.
Purpose of the Study:
- To investigate metabolic alterations in platelets activated by Toll-like receptors (TLRs).
- To explore the role of glycolysis and hexokinase (HK) in TLR-induced platelet activation and aggregation.
Main Methods:
- Analysis of metabolic reprogramming in TLR1/TLR2-activated platelets.
- Investigation of CD36-linked mechanisms in upregulated glycolysis.
- Assessment of hexokinase (HK) role in TLR1/TLR2-induced platelet aggregation.
Main Results:
- TLR1/TLR2 activation induces platelet glycolysis via CD36-dependent pathways.
- Hexokinase (HK) activity is critical for TLR1/TLR2-induced platelet aggregation.
- Platelet metabolic plasticity is altered upon TLR activation.
Conclusions:
- TLR-induced platelet activation involves significant metabolic reprogramming towards glycolysis.
- Targeting platelet metabolism, specifically hexokinase, may inhibit platelet function in TLR-mediated inflammatory diseases.
- Platelet metabolic plasticity presents a novel therapeutic avenue for inflammatory conditions involving TLRs.
Related Concept Videos
01:18Structure and Function of Platelets
1.5K
The cell fragments known as platelets are disc-shaped, with an average diameter of about 3 μm and a thickness of roughly 1 μm. They play a crucial role in the body's vascular clotting system, which also involves plasma proteins, blood cells, and blood vessel tissues.
Platelets are continually replenished, circulating in the bloodstream for 9-12 days before being removed by phagocytes, primarily in the spleen. A microliter of circulating blood contains between 150,000 and 450,000...
Platelets are continually replenished, circulating in the bloodstream for 9-12 days before being removed by phagocytes, primarily in the spleen. A microliter of circulating blood contains between 150,000 and 450,000...
1.5K
01:22Formation of the Platelet Plug
7.2K
The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
7.2K