Related Experiment Video
Updated: Jun 24, 2026
10:33
Generation of Alginate Microspheres for Biomedical Applications
Published on: August 12, 2012
21.1K
Engineering Moxifloxacin-Encapsulated Liposome-Enriched Alginate Hydrogel Films.
Ismail Bal1,2, Meltem Macit3, Ali Alasiri4
1Institute of Nanotechnology, Gebze Technical University, Kocaeli 41400, Turkey.
Gels (Basel, Switzerland)
|June 25, 2025
Summary
We developed a novel moxifloxacin (MXF)-loaded liposome hydrogel coating for sustained drug delivery. The T-shaped microfluidic junction method enhanced drug release stability for potential ophthalmic infection treatments.
Area of Science:
- Biomaterials Science
- Drug Delivery Systems
- Ophthalmology
Background:
- Developing advanced drug delivery systems is crucial for treating ophthalmic and mucosal membrane infections.
- Conventional treatments often face challenges with drug stability and sustained release.
- Liposome-encapsulated antibiotics offer potential for improved therapeutic outcomes.
Purpose of the Study:
- To develop and characterize a moxifloxacin (MXF)-encapsulated liposome-enriched alginate nanocomposite hydrogel coating.
- To compare the efficacy of micropipetting and T-shaped microfluidic junction (TMJ) device techniques for hydrogel coating fabrication.
- To evaluate the drug release profile and stability of the developed nanocomposite hydrogel coating.
Main Methods:
- Moxifloxacin (MXF) was encapsulated in soy lecithin liposomes with 80% efficiency using probe sonication.
- MXF-loaded liposomes were incorporated into alginate hydrogel matrices using micropipetting and TMJ device techniques.
- Nanocomposite hydrogel coatings were fabricated on a polymeric substrate.
- In vitro drug release studies were conducted to compare release profiles between the two fabrication methods.
Main Results:
- Drug encapsulation and hydrogel incorporation significantly enhanced MXF stability and prolonged its release.
- The TMJ device technique resulted in a more uniform hydrogel particulate structure compared to micropipetting.
- Sustained drug release was observed with the TMJ-fabricated hydrogel coating, whereas micropipetting showed a relatively rapid release.
- The nanocomposite hydrogel coatings demonstrated promising stability and controlled release characteristics.
Conclusions:
- The developed moxifloxacin-loaded liposome-enriched alginate nanocomposite hydrogel coatings exhibit enhanced stability and sustained drug release.
- The T-shaped microfluidic junction (TMJ) device technique is superior for achieving structural uniformity and controlled drug release compared to micropipetting.
- These advanced hydrogel coatings represent a promising platform for the treatment of ophthalmic and mucosal membrane infections.
Related Concept Videos
01:27Bioavailability Enhancement: Drug Permeability Enhancement
After oral administration, poor permeability often limits the rate at which drugs are absorbed through the intestinal epithelium. Enhancing drug permeability is crucial for effective therapy, and several strategies have been developed to overcome this challenge.One effective strategy involves the use of lipid-based formulations. These formulations enhance dissolution and solubility, targeting physiological mechanisms to increase drug absorption. This includes stimulating bile salt secretion,...
01:05Bioavailability Enhancement: Drug Stability Enhancement and GI Retention
Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...