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A Case Study on Fish Gelatin/Microcrystalline Cellulose Biomaterial Inks for Extrusion-Based Bioprinting.
Yubo Tao1, Jinbao Du1, Tong Hu1
1State Key Laboratory of Green Papermaking and Resource Recycling, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250353, China.
Gels (Basel, Switzerland)
|June 25, 2025
Summary
Fish gelatin reinforced with microcrystalline cellulose creates advanced biomaterial inks for 3D bioprinting. These novel inks enhance scaffold properties, offering a promising, cost-effective solution for tissue engineering.
Area of Science:
- Biomaterials Science
- Tissue Engineering
- Bioprinting Technology
Background:
- Developing printable, biocompatible, and biodegradable bioinks is crucial for extrusion-based bioprinting.
- Fish gelatin (FG) and microcrystalline cellulose (MCC) are explored as potential biomaterial components.
Purpose of the Study:
- To formulate and characterize novel FG/MCC composite biomaterial inks for 3D bioprinting.
- To evaluate the impact of MCC concentration on ink printability and scaffold properties.
Main Methods:
- Fabrication of 3D scaffolds using FG/MCC composite inks via extrusion bioprinting.
- Rheological analysis to assess ink properties.
- Fourier transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD) for material characterization.
- Evaluation of scaffold mechanical strength, porosity, degradation, swelling, and microarchitecture.
Main Results:
- Hydrogen bond formation between MCC and FG confirmed molecular-level interactions.
- MCC incorporation improved ink rheology and significantly enhanced scaffold compressive strength.
- MCC concentration modulated scaffold porosity, degradation rate, swelling behavior, and microarchitecture.
Conclusions:
- FG/MCC composite hydrogels demonstrate optimal properties for extrusion-based 3D bioprinting.
- This composite offers a promising, cost-effective platform for tissue engineering applications.
- The study highlights the potential of reinforced fish gelatin for advanced biomaterial development.
