Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Epigenetic Regulation01:37

Epigenetic Regulation

3.1K
Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
3.1K
Aging01:26

Aging

195
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
195
Telomeres and Telomerase02:41

Telomeres and Telomerase

5.4K
5.4K
Mitochondria01:37

Mitochondria

15.2K
Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
15.2K
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

2.6K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
2.6K
Replicative Cell Senescence02:15

Replicative Cell Senescence

3.8K
Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds...
3.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

EZH2 and intracellular Ca<sup>2+</sup> signals interdependently coordinate alloreactive and CAR-T-cell responses.

Cellular & molecular immunology·2026
Same author

Modeling age-related methylation changes in vitro with intestinal organoids.

BMC biology·2026
Same author

HIV Vpr induces demethylation of the SNCA antisense promoter, leading to neurocognitive impairment.

Scientific reports·2026
Same author

ZNFX1 Functions as a Master Regulator of Epigenetically Induced Pathogen Mimicry and Inflammasome Signaling in Cancer.

Cancer research·2025
Same author

Association between gut microbiota and CpG island methylator phenotype in colorectal cancer.

Gut microbes·2024
Same author

Genome-wide screening and functional validation of methylation barriers near promoters.

Nucleic acids research·2024
Same journal

Vigorous Physical Activity Mitigates Susceptibility to Obesity Associated with Risk Genotypes of <i>FTO</i> and <i>MC4R</i>, and <i>SREBF1</i> Is Hypermethylated: A Cross-Sectional Pilot Study.

Epigenomes·2026
Same journal

Remodelling of miRNA Regulatory Landscape During West Nile Virus (WNV) Infection.

Epigenomes·2026
Same journal

The Role of Epigenetics in Corneal Fibrosis.

Epigenomes·2026
Same journal

Dual Functionality of miRNAs During HIV Infection: From Viral Genome Suppression to Immune Response Modulation.

Epigenomes·2026
Same journal

Nuclear Transfer Perturbs Genomic Balance.

Epigenomes·2026
Same journal

5mC and 6mA DNA Methylation in the Fungal Kingdom: From Genome Defense to Epigenetic Regulation.

Epigenomes·2026
See all related articles

Related Experiment Video

Updated: Sep 18, 2025

Methylated DNA Immunoprecipitation
21:24

Methylated DNA Immunoprecipitation

Published on: January 2, 2009

23.5K

DNA Methylation, Aging, and Cancer.

Himani Vaidya1, Jaroslav Jelinek1, Jean-Pierre J Issa1

  • 1Coriell Institute for Medical Research, Camden, NJ 08103, USA.

Epigenomes
|June 25, 2025
PubMed
Summary
This summary is machine-generated.

Aging causes DNA methylation changes, increasing cancer risk. Understanding these epigenetic shifts offers new biomarkers and therapies for age-related diseases and cancer.

Keywords:
DNA methylationagingcancer

More Related Videos

Genome-Wide Analysis of DNA Methylation in Gastrointestinal Cancer
07:50

Genome-Wide Analysis of DNA Methylation in Gastrointestinal Cancer

Published on: September 18, 2020

5.7K
Sample Preparation to Bioinformatics Analysis of DNA Methylation: Association Strategy for Obesity and Related Trait Studies
14:56

Sample Preparation to Bioinformatics Analysis of DNA Methylation: Association Strategy for Obesity and Related Trait Studies

Published on: May 6, 2022

4.7K

Related Experiment Videos

Last Updated: Sep 18, 2025

Methylated DNA Immunoprecipitation
21:24

Methylated DNA Immunoprecipitation

Published on: January 2, 2009

23.5K
Genome-Wide Analysis of DNA Methylation in Gastrointestinal Cancer
07:50

Genome-Wide Analysis of DNA Methylation in Gastrointestinal Cancer

Published on: September 18, 2020

5.7K
Sample Preparation to Bioinformatics Analysis of DNA Methylation: Association Strategy for Obesity and Related Trait Studies
14:56

Sample Preparation to Bioinformatics Analysis of DNA Methylation: Association Strategy for Obesity and Related Trait Studies

Published on: May 6, 2022

4.7K

Area of Science:

  • Epigenetics and molecular biology
  • Gerontology and cancer research

Background:

  • Aging and cancer share molecular pathways, especially DNA methylation.
  • DNA methylation is crucial for gene expression, cellular identity, and genome stability.
  • Age-associated DNA methylation changes include global hypomethylation and focal hypermethylation.

Purpose of the Study:

  • To review how age-related DNA methylation changes contribute to cancer.
  • To explore mechanisms like DNA methylation drift, epigenetic clocks, and mosaicism in aging and cancer.
  • To highlight the potential of DNA methylation biomarkers and therapies for age-related diseases.

Main Methods:

  • Review of scientific literature on DNA methylation, aging, and cancer.
  • Discussion of epigenetic mechanisms and their role in tumorigenesis.
  • Analysis of translational potential for biomarkers and therapeutics.

Main Results:

  • Stochastic methylation errors accumulate with age, leading to epiallelic shifts and gene silencing.
  • These epigenetic alterations predispose tissues to malignant transformation.
  • Increased cancer incidence at younger ages may relate to accelerated epigenetic aging.

Conclusions:

  • Cancer can be viewed as a disease of accelerated epigenetic aging.
  • DNA methylation patterns offer insights into aging and cancer development.
  • Age-aware strategies are needed for cancer research and clinical oncology.