Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

107
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
107
Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

84
Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
84
Heart Failure Drugs: Diuretics01:22

Heart Failure Drugs: Diuretics

505
Heart failure and kidney perfusion are interconnected in a complex way. Reduced renal perfusion and venous congestion are two significant factors that contribute to renal dysfunction in heart failure. The kidneys, primarily responsible for fluid balance in the body, are adversely affected due to compromised cardiac output and increased venous pressure. In response to reduced renal perfusion, the kidneys activate neurohumoral mechanisms to restore balance. However, these mechanisms can be...
505
Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

76
Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
76
Chronic Kidney Disease IV: Nursing Management01:18

Chronic Kidney Disease IV: Nursing Management

61
Nursing management is essential for preventing complications, maintaining stability, and improving patients' quality of life in chronic kidney disease (CKD). By using a structured approach, nurses help slow CKD progression and support effective patient care​.1. Comprehensive patient assessmentEffective management begins with nurses reviewing the patient’s medical history, and identifying key risk factors like diabetes, hypertension, and nephrotoxic drug use. Nurses assess signs of...
61
Acute Kidney Injury II: Pathophysiology01:29

Acute Kidney Injury II: Pathophysiology

101
Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
101

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Bioactive Effects of Astragalus aureus Willd. Extracts on Antioxidant and Antimicrobial Properties and Shelf-Life Extension of Fish Fillets.

Applied biochemistry and biotechnology·2026
Same author

3D-printed lab-on-chip platforms for the detection of neurodegenerative diseases: opportunities and challenges.

Journal of materials chemistry. B·2026
Same author

Targeting α-Synuclein Aggregation in Parkinson's Disease: A Narrative Review of Current Gene Therapy Strategies.

Current neuropharmacology·2026
Same author

Synergistic microwave enzymatic immersion pretreatment of apple slices: Effects on mass transfer, enzyme activity, and digestive bioaccessibility.

Food chemistry·2026
Same author

Role of gut microbiota in cancer modulation: molecular mechanisms and emerging therapeutic strategies.

Infectious agents and cancer·2026
Same author

Microbiota-derived indole derivatives as anticancer agents: mechanistic insights and major perspectives.

Future microbiology·2026
Same journal

The Clinical Impact of Patient Embarrassment in Gynecology: A Comprehensive Review of Barriers, Consequences, and Mitigation Strategies.

Medical sciences (Basel, Switzerland)·2026
Same journal

Physical Performance as a Predictor of Length of Hospital Stay in Patients Undergoing Open-Heart Surgery: A Multicenter Prospective Study.

Medical sciences (Basel, Switzerland)·2026
Same journal

Renal Involvement in Pediatric Small-Vessel Vasculitis: A Comprehensive Review of Clinical Impact, Diagnosis, and Management.

Medical sciences (Basel, Switzerland)·2026
Same journal

MRI-Based Radiomics and Artificial Intelligence for Prediction of Recurrence and Prognostic Outcomes in Oral Tongue Squamous Cell Carcinoma: A Systematic Review with Functional Meta-Synthesis.

Medical sciences (Basel, Switzerland)·2026
Same journal

Present and Future Options for Pharmacotherapy in Cardiovascular Disease: Hemodynamic and Mechanistic Therapeutic Targets.

Medical sciences (Basel, Switzerland)·2026
Same journal

Narrative Review of Digital Twins in the Health Domain: Development, Application, and Evidence Consolidation.

Medical sciences (Basel, Switzerland)·2026
See all related articles

Related Experiment Video

Updated: Sep 18, 2025

Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

16.4K

Exploring the Interplay Between Kidney Dysfunction and Cardiovascular Disease.

Rajesh Yadav1, Aqsa Kaim Abubakar1, Richa Mishra2

  • 1Department of Dialysis Technology, Sharda School of Allied Health Sciences, Sharda University, Greater Noida 201310, Uttar Pradesh, India.

Medical Sciences (Basel, Switzerland)
|June 25, 2025
PubMed
Summary
This summary is machine-generated.

This review details complications from dialysis and chronic kidney disease (CKD), focusing on cardiovascular issues and hemodialysis-related problems. Understanding these risks is crucial for managing end-stage renal disease patients.

Keywords:
cardiovascular diseasechronic kidney diseasehemodialysisnitric oxide signaling

More Related Videos

A Mouse 5/6th Nephrectomy Model That Induces Experimental Uremic Cardiomyopathy
07:52

A Mouse 5/6th Nephrectomy Model That Induces Experimental Uremic Cardiomyopathy

Published on: November 7, 2017

21.0K
Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
10:31

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice

Published on: May 2, 2025

292

Related Experiment Videos

Last Updated: Sep 18, 2025

Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

16.4K
A Mouse 5/6th Nephrectomy Model That Induces Experimental Uremic Cardiomyopathy
07:52

A Mouse 5/6th Nephrectomy Model That Induces Experimental Uremic Cardiomyopathy

Published on: November 7, 2017

21.0K
Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
10:31

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice

Published on: May 2, 2025

292

Area of Science:

  • Nephrology
  • Cardiology
  • Internal Medicine

Background:

  • Chronic kidney disease (CKD) impairs kidney function, necessitating hemodialysis for end-stage renal disease.
  • Hemodialysis involves filtering blood externally, requiring arteriovenous (AV) fistula creation.
  • CKD is strongly linked to cardiovascular disease (CVD) development.

Purpose of the Study:

  • To review the spectrum of complications associated with dialysis and kidney disease.
  • To highlight cardiovascular complications in CKD patients undergoing hemodialysis.
  • To discuss the molecular mechanisms of CVD in CKD, including nitric oxide (NO) signaling.

Main Methods:

  • This is a review article, synthesizing existing research on dialysis and CKD complications.
  • It examines complications arising from the hemodialysis procedure itself.
  • It explores the molecular pathways contributing to cardiovascular disease in CKD.

Main Results:

  • Patients with CKD experience numerous complications, including left ventricular hypertrophy, heart failure, arrhythmias, and coronary heart disease.
  • Hemodialysis, while life-sustaining, can lead to complications such as AV fistula failure and intradialytic hypertension.
  • Molecular mechanisms, like altered nitric oxide (NO) signaling, contribute to CVD in CKD patients.

Conclusions:

  • Dialysis and CKD present significant risks for cardiovascular morbidity and mortality.
  • Proper AV fistula creation and management, alongside diligent patient care, are essential to mitigate hemodialysis-related complications.
  • Further research into the molecular underpinnings of CVD in CKD is warranted to improve patient outcomes.