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Ultrasound-Mediated Membrane Modulation for Biomedical Applications.
Jinhee Yoo1, Dasom Heo2, Yunhee Hwang2
1Department of Biophysics, Institute of Quantum Biophysics, Sungkyunkwan University, Suwon 16419, Republic of Korea.
Nanomaterials (Basel, Switzerland)
|June 25, 2025
Summary
Ultrasound non-invasively modulates cell membranes through cavitation, sonoporation, and mechanotransduction. This technology offers diverse biomedical applications in drug delivery, therapeutics, and diagnostics, bridging research and clinical practice.
Area of Science:
- Biophysics
- Biomedical Engineering
- Cell Biology
Background:
- The cell membrane is crucial for homeostasis and cellular responses.
- Traditional physical stimuli have limitations in cell membrane research.
- Ultrasound offers a non-invasive, deep-penetrating alternative for studying cell membranes.
Purpose of the Study:
- To review ultrasound's interaction mechanisms with cell membranes.
- To highlight the biomedical applications of ultrasound-mediated membrane modulation.
- To discuss challenges and future directions in the field.
Main Methods:
- Cavitation: Ultrasound-induced bubble formation and collapse near membranes.
- Sonoporation: Ultrasound-induced transient membrane pores.
- Mechanotransduction: Ultrasound-generated forces triggering cellular signaling.
Main Results:
- Ultrasound interactions (cavitation, sonoporation, mechanotransduction) alter cell membrane properties.
- These interactions enable applications in targeted drug delivery.
- Ultrasound facilitates novel therapeutic and diagnostic strategies.
Conclusions:
- Ultrasound-mediated membrane modulation is a versatile tool.
- It bridges fundamental cell biology research with clinical applications.
- Further research can enhance its clinical and diagnostic potential.
