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Identification and Analysis of Differentially Expressed Ferroptosis-Related Genes in Microtia

Jingyang Zhou1, Runmeng Cui, Lin Lin

  • 1Ear Reconstruction Center, Plastic Surgery Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China.

The Journal of Craniofacial Surgery
|June 25, 2025
PubMed

Insights

This study reveals a genetic link between microtia, a congenital ear deformity, and ferroptosis, a cell death process. Key ferroptosis-related genes and transcription factors were identified, suggesting ferroptosis

Area of Science:

  • Genetics
  • Biochemistry
  • Developmental Biology

Background:

  • Microtia is a congenital deformity of the auricle, potentially linked to abnormal auricular cartilage development during gestation.
  • Ferroptosis, a regulated cell death pathway, has been implicated in various cartilage-related diseases.

Purpose of the Study:

  • To investigate the genetic relationship between microtia and ferroptosis using bioinformatics.
  • To identify key genes and regulatory factors involved in this association for future research.

Main Methods:

  • Utilized the gene expression profile GSE242921.
  • Cross-referenced with the FerrDB database to identify differentially expressed ferroptosis-related genes in microtia.
  • Analyzed transcription factors associated with these genes.

Main Results:

  • Identified 10 differentially expressed ferroptosis-related genes: STAT3, CDH1, HRAS, CDKN2A, SLC1A5, PTPN6, DDR2, FURIN, SMAD7, and IFNA6.
  • Determined transcription factors FOXC1, USF2, GATA2, CREB1, E2F1, and TFAP2A (degree ≥5) regulate these genes.
  • Established a significant genetic link between ferroptosis and microtia.

Conclusions:

  • A notable genetic connection exists between ferroptosis and microtia.
  • Further experimental validation is required to elucidate the precise genetic mechanisms of ferroptosis in microtia pathogenesis.
Keywords:
Bioinformatics analysisferroptosismicrotia

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