Related Experiment Video
Updated: Sep 18, 2025

Author Spotlight: Hypothalamic Neural Mechanism Insights
Published on: August 4, 2023
BBSome: An essential component of hypothalamic regulation of energy homeostasis
Deng Fu Guo1,2, Yuying Zhao1, Connor Laule1
1Department of Neuroscience and Pharmacology, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
Abstract:
The BBSome is a protein complex composed of eight Bardet-Biedl syndrome (BBS) proteins. Although the BBSome is best known for its role in regulating cilia function, accumulating evidence indicates that this protein complex is also involved in various cellular processes, including mitochondrial dynamics and receptor trafficking to the plasma membrane. BBSome deficiency is associated with a range of diseases, including obesity and type 2 diabetes. Research into the mechanisms underlying metabolic disorders caused by BBSome deficiency has uncovered novel pathways of metabolic regulation, particularly within the hypothalamus. In this review, we discuss recent advances in understanding the role of the hypothalamic BBSome in the control of energy and glucose homeostasis and explore the underlying mechanisms.
More Related Videos
08:32Studying the Hypothalamic Insulin Signal to Peripheral Glucose Intolerance with a Continuous Drug Infusion System into the Mouse Brain
Published on: January 4, 2018
06:57Determining Basal Energy Expenditure and the Capacity of Thermogenic Adipocytes to Expend Energy in Obese Mice
Published on: November 11, 2021
Related Concept Videos
Regulation of Food Intake
Primary Motives: Hunger and Thirst
Hunger arises when the brain detects changes in the body's nutrient levels, including glucose, lipids, amino acids, and hormones such as ghrelin and leptin. The hypothalamus plays a central role in hunger regulation. The lateral hypothalamus...
Regulation of Metabolism
Diencephalon: Hypothalamus and Coordination
The hypothalamus interacts with other brain regions, including the pituitary gland, through a direct physical connection called the hypothalamic-pituitary axis. The hypothalamus receives somatic and visceral inputs and...
Feedback Loops
Homeostatic Imbalance
However, sometimes these feedback loops fail,...