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Updated: Sep 18, 2025

Synthesis of Indoxyl-glycosides for Detection of Glycosidase Activities
Published on: May 27, 2015
β-Arylation of Indanone Derivatives via α-Carbamoylation/Elimination of Isocyanate Sequence
Moe Morimoto1, Ryoma Shimazumi1, Vishal Kumar Rawat1
1Department of Applied Chemistry, Graduate School of Engineering, The University of Osaka, Suita, Osaka 565-0871, Japan.
Abstract:
β-Aryl carbonyl compounds are crucial motifs in pharmaceuticals and bioactive molecules, yet their synthesis from saturated carbonyl compounds remains a significant challenge. We report a practical and operationally simple protocol for β-arylation of cyclic carbonyl compounds, which seamlessly integrates with α-functionalization methods, enabling rapid, stereoselective construction of multisubstituted carbonyl compounds. The simplicity, broad applicability, and mechanistic insights provided by this β-arylation protocol establish it as a valuable tool for streamlined synthesis of complex carbonyl frameworks.
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