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Right versus left lung cancer: Findings from the Japanese cancer registry database

  • 0Chiba Cancer Center Research Institute, Chiba, Japan.
Cancer Epidemiology +

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June 25, 2025

|

June 25, 2025

View abstract on PubMed

Summary

This summary is machine-generated.

Right-sided lung cancer is more common and associated with a slightly higher mortality risk, particularly in males. These findings on lung cancer laterality offer insights into its development and personalized treatment strategies.

Area Of Science

  • Oncology
  • Medical Research

Background

  • Laterality, or body side difference, is a potential factor in cancer development.
  • Previous studies suggest variations in lung cancer incidence between right and left lungs due to anatomical, genetic, and environmental factors.

Purpose Of The Study

  • To investigate the relationship between lung cancer laterality, incidence, and prognosis.
  • To compare patient characteristics and survival outcomes based on lung cancer side.

Main Methods

  • A cohort study utilizing data from the Chiba Prefecture Cancer Registry (2013-2020) of 36,502 primary lung cancer patients.
  • Statistical analyses included Kaplan-Meier curves, log-rank tests, and Cox proportional hazards models, adjusted for key patient covariates.

Main Results

  • Right-sided lung cancer was more prevalent (60%) than left-sided (40%).
  • Right-sided lung cancer showed a slightly higher mortality rate (HR: 1.05, p=0.003).
  • Males with right-sided cancer had a higher mortality risk (HR: 1.08, p<0.001), while no significant difference was observed in females.

Conclusions

  • The higher prevalence of right-sided lung cancer may be linked to anatomical and genetic factors.
  • While the clinical impact of laterality is minimal, findings contribute to understanding lung cancer pathogenesis.
  • Results may aid in advancing personalized medicine approaches for lung cancer.

Keywords:

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