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[Genetic Causes of Heart Failure in Adults]

Brenda Gerull

    Deutsche Medizinische Wochenschrift (1946)
    |June 25, 2025
    PubMed

    Insights

    Hereditary cardiomyopathies are genetic heart muscle disorders causing heart failure. Genetic testing and family screening are crucial for diagnosis, prognosis, and personalized treatment strategies.

    Area of Science:

    • Cardiology
    • Genetics
    • Precision Medicine

    Background:

    • Genetic factors are key in personalized heart failure care.
    • Hereditary cardiomyopathies are a major cause of heart failure.
    • These disorders present diverse clinical phenotypes.

    Purpose of the Study:

    • To explore hereditary cardiomyopathies and their role in heart failure.
    • To highlight the importance of genetic testing and counseling.
    • To discuss genotype-specific strategies for precision medicine.

    Main Methods:

    • Multiparametric diagnosis including clinical evaluation, ECG, imaging, and genetic testing.
    • Genetic counseling and testing for subtyping, prognosis, and therapy.
    • Family cascade screening for early detection and risk stratification.

    Main Results:

    • Hereditary cardiomyopathies are classified into HCM, DCM, NDLVC, ARVC, and RCM.
    • Genetic testing aids precise subtyping and guides therapy.
    • Family screening identifies carriers and optimizes follow-up.

    Conclusions:

    • Genetic factors are pivotal in managing heart failure.
    • Personalized, genotype-specific strategies are advancing precision cardiology.
    • Early genetic diagnosis and family screening improve patient outcomes.

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