Synthesis of aceclofenac and L-Arginine salt, characterization and bioactivities

Molecular salt synthesis is promising technique for increasing the bioavailability and solubility of the FDA-drugs. The present investigations focus on the synthesis of aceclofenac salt in a 1:1 molar ratio, employing the rapid solvent evaporation precipitation technique in conjunction with the coformor l-arginine. The salt was characterized through Fourier Transform Infrared (FTIR), Differential Scanning Calorimeter (DSC), Powder X-ray Diffraction (PXRD) and Thermo Gravimetric Analysis (TGA). FTIR analysis and DSC results revealed that ACF and ARG interact with each other; the valuable changes observed in ACF-ARG FTIR spectrum and DSC thermogram. PXRD patterns demonstrated that the prepared salt exhibited a unique crystalline phase compared to the starting materials. TGA analysis confirmed the salt is an anhydrous nature as no considerable mass loss observed up to melting temperature. Furthermore, the synthesized salt showed potent anti-inflammatory and cytotoxic activities. It can be concluded that drug co-crystallization using conformer is a new era for the exploration of drug pharmacokinetics.