Quaternary ammonium-modified dextran: a unique biodegradable mucoadhesive polymer.
Khush Bakhat Afzal1, Gergely Kali1, Muhammad Haris2
1Center for Chemistry and Biomedicine, Department of Pharmaceutical Technology, Institute of Pharmacy, University of Innsbruck, Innrain 80/82 6020 Innsbruck, Austria.
Summary
A novel cationic dextran polymer was developed for enhanced mucoadhesion and biocompatibility. This modified dextran shows significant potential for biomedical applications due to its improved interaction with mucus and tissues.
Area of Science:
- Polymer Chemistry
- Biomaterials Science
- Drug Delivery
Background:
- Dextran is a polysaccharide with limited mucoadhesive properties.
- Developing biocompatible polymers with enhanced mucoadhesion is crucial for drug delivery systems.
Purpose of the Study:
- To synthesize and characterize a cationic dextran polymer.
- To evaluate its mucoadhesive properties and biocompatibility for potential biomedical applications.
Main Methods:
- Quaternary ammonium-modified dextran synthesized via esterification.
- Characterization included zeta potential, NMR, FTIR, and enzymatic degradation.
- In vitro cytotoxicity, hemolysis, and rheometric mucoadhesion studies were performed.
Main Results:
- Successful synthesis of cationic dextran confirmed by structural analysis.
- Modified dextran exhibited no significant toxicity up to 0.5% concentration.
- Demonstrated 3.4-fold higher mucoadhesion and increased viscosity compared to native dextran.
Conclusions:
- Quaternary ammonium-modified dextran is a biocompatible and biodegradable polymer.
- The cationic nature significantly enhances mucoadhesive properties.
- Shows promise for advanced drug delivery and biomedical applications.
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