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Inhibiting multidrug resistant Shigella flexneri using comparative genomics guided In vitro and In silico screening.

Sarmishta Mukhopadhyay1, Fernando Berton Zanchi2, Gaurab Aditya Dhar1

  • 1Post Graduate and Research Department of Biotechnology, St. Xavier's College (Autonomous) Kolkata, West Bengal, India.

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|June 25, 2025
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Summary
This summary is machine-generated.

Two medicinal plant extracts, Psidium guajava and Scoparia dulcis, show promise against multidrug-resistant Shigella flexneri. This research explores novel phytopharmaceuticals to combat shigellosis, a major infant diarrheal disease.

Keywords:
Antimicrobial activityMolecular dockingPhytotherapyShigella flexneriTranscriptome profiling

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Area of Science:

  • Microbiology
  • Pharmacology
  • Computational Biology

Background:

  • Shigella infection causes significant infant diarrheal mortality globally.
  • Rising antibiotic resistance and emerging strains necessitate new treatments for shigellosis.

Purpose of the Study:

  • To evaluate the in-vitro antibacterial activity of medicinal plants against multidrug-resistant Shigella flexneri.
  • To identify potential phytopharmaceuticals for treating shigellosis.

Main Methods:

  • Virtual screening, molecular docking, and molecular dynamic simulations were employed to identify active natural compounds.
  • Comparative transcriptome analysis and qRT-PCR were used to understand the antimicrobial mechanisms.

Main Results:

  • Extracts from Psidium guajava and Scoparia dulcis demonstrated viable therapeutic potential against multidrug-resistant Shigella.
  • Specific compounds like 5-Hydroxy-1-isopropyl-6,6-dimethyl-5-phenyl-piperidin-2-one and limonene were identified as prospective agents.

Conclusions:

  • Psidium guajava and Scoparia dulcis offer promising phytopharmaceutical candidates for controlling Shigella infections.
  • Further research may lead to the development of novel treatments to combat Shigella superbugs.