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Intravascular ultrasound guidance for complex high-risk indicated procedures in underrepresented patient populations

Ernest Spitzer1, Ximena S Paredes2, J Dawn Abbott3

  • 1European Cardiovascular Research Institute, Rotterdam, the Netherlands; Cardialysis, Rotterdam, the Netherlands.

Cardiovascular Revascularization Medicine : Including Molecular Interventions
|June 25, 2025
PubMed

Insights

Intravascular ultrasound (IVUS) guidance improves percutaneous coronary intervention (PCI) outcomes in complex coronary lesions for minority populations. This registry study assessed IVUS-guided PCI safety and efficacy in underrepresented patients with high-risk procedures.

Area of Science:

  • Cardiology
  • Interventional Cardiology
  • Medical Devices

Background:

  • Intravascular ultrasound (IVUS) is recommended for percutaneous coronary intervention (PCI) in complex coronary lesions.
  • Complex coronary anatomy affects up to one-third of patients, correlating with poorer outcomes.
  • Limited data exists on lesion characteristics and outcomes in minority patient groups.

Purpose of the Study:

  • To evaluate the safety and efficacy of IVUS-guided PCI in underrepresented minority populations undergoing complex high-risk procedures.
  • To assess procedural and clinical outcomes in this specific patient demographic.

Main Methods:

  • Prospective, observational, multicenter, single-arm study (IVUS CHIP UPP Registry).
  • Included ~1010 subjects identifying within a demographic minority undergoing complex high-risk PCI.
  • Defined optimal stenting criteria and assessed target-vessel failure at 1 year.

Main Results:

  • The study focused on safety and efficacy of IVUS-guided PCI in a minority population.
  • Specific criteria for optimal stenting were applied.
  • Primary endpoint was target-vessel failure at 1 year, with secondary procedural and imaging endpoints.

Conclusions:

  • The IVUS CHIP UPP Registry is the first prospective study of its kind.
  • It investigates IVUS-guided PCI outcomes in complex coronary lesions among US minority populations.
  • Provides crucial data on managing complex coronary artery disease in underrepresented groups.
Abstract

Keywords:
Complex high-risk indicated proceduresIntravascular ultrasound

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