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Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT01:25

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Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...
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Decrease in Calcifications After Neoadjuvant Treatment Predicts Invasive Tumor Response but Not Complete DCIS

Noam Weiner1, Yaron Niv2, Eran Sharon1

  • 1Breast Surgery Unit, Department of Surgery, Rabin Medical Center-Beilinson Hospital, Petach Tikva, Israel; Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Clinical Breast Cancer
|June 25, 2025
PubMed
Summary
This summary is machine-generated.

Decreased breast cancer calcifications after neoadjuvant treatment significantly predict pathologic complete response. This finding may help guide surgical planning post-treatment.

Keywords:
Breast cancerBreast imagingMicrocalcificationsNeoadjuvant systemic therapyPathologic complete response

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Area of Science:

  • Oncology
  • Radiology
  • Pathology

Background:

  • The relationship between changes in breast cancer calcifications and treatment response is not well understood.
  • Neoadjuvant treatment aims to shrink tumors before surgery, and assessing response is crucial.

Purpose of the Study:

  • To systematically review and meta-analyze studies evaluating the association between calcification changes post-neoadjuvant treatment and pathologic complete response (pCR) in breast cancer.

Main Methods:

  • Systematic literature search of PubMed and EMBASE for relevant English-language studies.
  • Meta-analysis using random-effects model to calculate pooled odds ratios and confidence intervals.
  • Assessment of study heterogeneity, publication bias, and quality.

Main Results:

  • Eight studies with 707 patients were included. Decreased calcifications after neoadjuvant treatment were associated with significantly higher odds of achieving pCR (OR=1.691, p<0.001).
  • Subgroup analyses confirmed significance for decrease vs. no-decrease (OR=2.045, p=0.004).
  • The association remained significant when residual ductal carcinoma in situ (DCIS) was permitted in the pCR definition (OR=2.196, p<0.001).

Conclusions:

  • A decrease in breast cancer calcifications following neoadjuvant therapy is a strong predictor of pCR.
  • Calcification changes can potentially serve as an additional imaging biomarker to aid in surgical planning after neoadjuvant treatment.