NF-κB in inflammation and cancer

Area of Science:

• Molecular Biology
• Immunology
• Oncology

Background:

• Nuclear factor-kappa B (NF-κB) is a transcription factor family regulating immune responses, inflammation, cell growth, and survival.
• Dysregulated NF-κB activation is implicated in inflammatory disorders, autoimmune diseases, and cancer development.
• NF-κB's role in oncogenesis includes promoting tumor cell proliferation, survival, metabolism, metastasis, angiogenesis, and therapy resistance.

Purpose of the Study:

• To review recent findings on the role of NF-κB in pathological processes.
• To discuss the underlying mechanisms of NF-κB's involvement in disease.
• To explore therapeutic strategies targeting the NF-κB pathway and analyze potential challenges.

Main Methods:

• Literature review of recent scientific findings.
• Analysis of molecular mechanisms.
• Exploration of therapeutic strategies and challenges.

Main Results:

• NF-κB dysregulation contributes to inflammatory and autoimmune diseases.
• NF-κB is linked to cancer development and progression.
• Targeting NF-κB presents therapeutic potential for inflammatory diseases and cancer.

Conclusions:

• NF-κB is a critical mediator in inflammation and cancer.
• Targeting the NF-κB pathway is a promising therapeutic avenue.
• Further research is needed to overcome challenges in NF-κB-targeted therapies.