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Updated: Sep 18, 2025
Structure-function Studies in Mouse Embryonic Stem Cells Using Recombinase-mediated Cassette Exchange
Published on: April 27, 2017
The expanding repertoire of ESCRT functions in cell biology and disease
James H Hurley1,2,3, Alyssa N Coyne4,5, Marta Miączyńska6
1Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA. jimhurley@berkeley.edu.
Abstract:
The endosomal sorting complex required for transport (ESCRT) is a multicomplex machinery comprising proteins that are conserved from bacteria to humans and has diverse roles in regulating the dynamics of cellular membranes. ESCRT functions have far-reaching consequences for cell biological processes such as intracellular traffic, membrane repair, cell signalling, metabolic regulation, cell division and genome maintenance. Here we review recent insights that emphasize the pathophysiological consequences of ESCRT dysfunctions, including infections, immune disorders, cancers and neurological diseases. We highlight the possibilities of using our knowledge about ESCRT structures and functions for drug discovery.
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