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Related Concept Videos

The Effect of Aging on Tissues01:19

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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
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Osteoimmunology and aging - a frontier to explore.

Mihailo Ille1, Iannis E Adamopoulos2, Mindy J Fain3,4

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Geriatric osteoimmunology explores the aging interplay between skeletal and immune systems. Cellular senescence in osteoarthritis and osteoporosis may offer new diagnostic and therapeutic targets for age-related diseases.

Keywords:
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Area of Science:

  • Geriatric osteoimmunology
  • Immunology
  • Skeletal biology

Background:

  • Osteoimmunology examines the bidirectional communication between skeletal and immune systems.
  • Bone marrow serves as a critical microenvironment for immune cell development and systemic communication.
  • Cytokines like RANKL and mediators such as OPG, produced by immune and bone cells, respectively, regulate each other's function.

Purpose of the Study:

  • To review current knowledge and identify knowledge gaps in geriatric osteoimmunology.
  • To focus on osteoarthritis and osteoporosis as prevalent aging diseases.
  • To explore the role of cellular senescence in the pathogenesis of these conditions.

Main Methods:

  • This is a perspective paper, outlining current understanding and knowledge gaps.
  • Literature review and synthesis of existing research in geriatric osteoimmunology.
  • Focus on pathogenetic mechanisms, particularly cellular senescence.

Main Results:

  • Dysregulation of skeletal and immune systems in aging significantly impacts healthspan.
  • Cellular senescence is implicated as a key pathogenetic factor in osteoarthritis and osteoporosis.
  • Understanding these interactions may reveal new diagnostic and therapeutic strategies.

Conclusions:

  • Geriatric osteoimmunology is crucial for understanding age-related diseases.
  • Cellular senescence presents a promising target for future interventions in osteoarthritis and osteoporosis.
  • Further research is needed to translate these findings into clinical practice.