In Vitro Evaluation of the Effect of Stenting on Hematological, Hemorheological and Hemodynamic Parameters, in

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Experimental Investigation of Secondary Flow Structures Downstream of a Model Type IV Stent Failure in a 180° Curved Artery Test Section
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Experimental Investigation of Secondary Flow Structures Downstream of a Model Type IV Stent Failure in a 180° Curved Artery Test Section

Published on: July 19, 2016

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D Kokkinidou1, K Kapnisis1, M Chrysostomou1

  • 1Department of Mechanical Engineering and Materials Science and Engineering, Cyprus University of Technology, Limassol, Cyprus.

Cardiovascular Engineering and Technology
|June 25, 2025
PubMed

Insights

Stent implantation during percutaneous coronary intervention affects blood flow. This study found changes in red blood cell aggregation and pressure drop, particularly with specific stent configurations and higher flow rates.

Area of Science:

  • Biomedical Engineering
  • Cardiovascular Science
  • Hemodynamics

Background:

  • Percutaneous coronary intervention (PCI) is a common procedure to restore blood flow in diseased arteries.
  • The impact of stent implantation on blood physiology and flow dynamics remains incompletely understood.
  • Investigating stent-induced alterations in hematological, hemorheological, and hemodynamic parameters is crucial for optimizing PCI outcomes.

Purpose of the Study:

  • To evaluate the effects of stent implantation on hematological, hemorheological, and hemodynamic parameters.
  • To assess how different stent configurations and flow conditions influence blood flow characteristics.
  • To understand the physiological consequences of stented coronary artery morphologies.

Main Methods:

  • Simulated blood flow through single and overlapping stent models in straight and curved tubes.
  • Utilized two flow regimes (physiological and intense) to mimic diverse conditions.
  • Analyzed blood samples for hematology, red blood cell (RBC) deformability and aggregation, and viscosity; measured pressure drop across stents.

Main Results:

  • Minor alterations in RBC count, hematocrit, and mean corpuscular volume observed due to prolonged stress.
  • Significant increase in RBC aggregation noted, especially in the female cohort.
  • Stent configuration influenced pressure drop, and blood viscosity was affected at higher flow rates.

Conclusions:

  • Stent presence distinctly alters specific hemorheological and hemodynamic parameters.
  • The observed changes are dependent on the experimental setup and stent configuration.
  • Findings highlight the need for further research into stent design and its physiological impact.
Abstract

Keywords:
HematologyHemodynamicsHemorheologyPressure-dropRed blood cell biomechanicsStent-induced changesStents

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