Emerging Trends in Green Extraction Techniques, Chemical Modifications, and Drug Delivery Systems for Resveratrol

Area of Science:

• Natural Product Chemistry
• Pharmacology
• Drug Delivery

Background:

• Resveratrol is a natural phytoalexin with antioxidant, anti-inflammatory, and anticancer properties.
• Poor aqueous solubility and rapid degradation limit resveratrol's clinical application due to low bioavailability.
• Recent research focuses on overcoming these limitations for pharmaceutical development.

Purpose of the Study:

• To review recent advancements (last 5 years) in resveratrol research.
• To explore sustainable extraction, structure-activity relationships, and drug delivery systems.
• To enhance resveratrol's bioavailability and therapeutic efficacy.

Main Methods:

• Green extraction techniques for efficient and sustainable resveratrol isolation.
• Structure-activity relationship (SAR) studies of resveratrol derivatives.
• Development of advanced drug delivery systems for improved solubility, stability, and targeted delivery.

Main Results:

• Innovative green extraction methods offer sustainable resveratrol isolation.
• Resveratrol derivatives show potential for improved bioavailability and therapeutic activity.
• Advanced delivery systems enhance solubility, stability, and targeted tissue delivery.

Conclusions:

• Optimizing extraction, derivatization, and delivery is crucial for maximizing resveratrol's clinical potential.
• These strategies collectively aim to overcome bioavailability challenges.
• Effective pharmaceutical formulations can be developed by enhancing resveratrol's stability and solubility.