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Transcript PHF19-207 as a Potential Biomarker for Colon Cancer Diagnosis and Screening.

Stefan Kmezic1,2, Sandra Dragicevic3, Tamara Babic3

  • 1Clinic for Digestive Surgery, University Clinical Center of Serbia, dr Koste Todorovica 6, 11 000 Belgrade, Serbia.

Biomolecules
|June 26, 2025
PubMed
Summary

The PHF19-207 transcript shows promise as a biomarker for colon cancer detection. Its elevated expression in tumor and polyp tissues suggests potential for improved colorectal cancer screening and diagnosis.

Keywords:
PHF19cancer diagnosiscancer screeningcolon cancergene expressiontranscript

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Area of Science:

  • Oncology
  • Molecular Diagnostics
  • Biomarker Discovery

Background:

  • Colorectal cancer (CRC) incidence is rising, particularly in younger demographics.
  • There is a critical need for enhanced early detection and diagnostic tools.
  • Previous pan-cancer studies identified PHF19-207 as a potential colon cancer biomarker.

Purpose of the Study:

  • To evaluate the expression of the PHF19-207 transcript in colon tissue samples.
  • To assess the diagnostic and screening utility of PHF19-207 in different clinical settings.
  • To correlate PHF19-207 expression with tumor characteristics.

Main Methods:

  • Analysis of PHF19-207 expression in surgical colon tumor and non-tumor tissues.
  • Examination of PHF19-207 expression in biopsied samples from national colorectal cancer screening participants.
  • Quantification of PHF19-207 levels using Real-Time Polymerase Chain Reaction (RT-PCR).
  • Statistical analysis including Receiver Operating Characteristic (ROC) curve analysis.

Main Results:

  • PHF19-207 expression was significantly higher in tumor tissue compared to non-tumor tissue (p = 0.002).
  • Tumor tissue and polyp samples showed significantly elevated PHF19-207 levels versus healthy mucosa (p < 0.001 and p = 0.035, respectively).
  • ROC analysis demonstrated PHF19-207's effectiveness in distinguishing malignant from healthy tissue (AUC = 0.9044).

Conclusions:

  • PHF19-207 expression is significantly altered in colon tumors and polyps.
  • The transcript demonstrates strong potential as a diagnostic biomarker for colon cancer.
  • PHF19-207 could form the basis for a novel, efficient, and affordable colorectal cancer screening test.