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Updated: Sep 18, 2025
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A Doxorubicin-induced Cardiomyopathy Model in Adult Zebrafish
Published on: June 7, 2018
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Non-Coding RNAs in the Regulation of Doxorubicin-Induced Cardiotoxicity
Mengyao Sun1,2, Il-Man Kim2, Lei Yang1,2
1Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Biomolecules
|June 26, 2025
Summary
Non-coding RNAs (ncRNAs) are key regulators of doxorubicin-induced cardiotoxicity (DIC). Understanding ncRNA mechanisms offers new cardioprotective strategies against this chemotherapy side effect.
Area of Science:
- Biochemistry
- Molecular Biology
- Cardiology
Background:
- Doxorubicin chemotherapy causes cardiotoxicity, limiting its use.
- Non-coding RNAs (ncRNAs) are increasingly recognized in regulating this toxicity.
- ncRNAs influence cell death, oxidative stress, and mitochondrial dysfunction in cardiotoxicity.
Purpose of the Study:
- To review the molecular mechanisms of ncRNAs in doxorubicin-induced cardiotoxicity (DIC).
- To explore ncRNAs as potential targets for cardioprotective strategies.
Main Methods:
- Literature review of recent studies on ncRNAs and DIC.
- Analysis of ncRNA interactions with DNA, RNA, proteins, and lipids.
- Focus on cellular processes involved in DIC pathophysiology.
Main Results:
- ncRNAs (miRNAs, lncRNAs, circRNAs) play critical roles in DIC.
- ncRNAs modulate gene expression impacting cardiac cells.
- These interactions present therapeutic intervention points.
Conclusions:
- ncRNAs are essential regulators of doxorubicin-induced cardiotoxicity.
- Further understanding of ncRNA roles can lead to novel cardioprotective therapies.
- Targeting ncRNAs may mitigate doxorubicin's adverse cardiac effects.
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