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Published on: October 8, 2016
Biological Nanocarriers in Cancer Therapy: Cutting Edge Innovations in Precision Drug Delivery
Ramesh Ganpisetti1, Sanjay Giridharan2, G S Sainaga Jyothi Vaskuri3
1Terasaki Institute of Biomedical Sciences, 21100 Erwin St, Woodland Hills, Los Angeles, CA 91367-3712, USA.
Abstract:
Cancer is a highly detrimental and fatal illness that poses a significant threat to human well-being. The pattern of cancer treatment is continuously being optimized by the advancement of old treatment approaches and the invention of novel treatment modes. Nanotechnology-based approaches are emerging as powerful candidates in the development of these advanced methods for treating tumors. This article provides a concise overview of nanotechnology for cancer or cancer nanomedicine and its applications. In light of prevalent issues, such as inadequate precision in targeting initial chemotherapy drugs, susceptibility of nucleic acid drugs to degradation, gene delivery, and the occurrence of common immune-related adverse events during immunotherapy, we explore the potential integration of nanomedicine with these treatment approaches and illustrative examples and highlight the benefits that arise from the utilization of nanomedicine.
Insights
Nanomedicine enhances cancer treatment by improving drug targeting and delivery. This approach addresses limitations in chemotherapy and immunotherapy, offering advanced solutions for tumor treatment.
Area of Science:
- Oncology
- Biomedical Engineering
- Materials Science
Background:
- Cancer remains a significant global health challenge, necessitating innovative treatment strategies.
- Current cancer therapies face limitations including poor drug targeting, drug degradation, and adverse immune reactions.
- Nanotechnology offers promising solutions to overcome these therapeutic challenges.
Purpose of the Study:
- To provide a concise overview of nanotechnology in cancer treatment (cancer nanomedicine).
- To explore the integration of nanomedicine with existing cancer therapies like chemotherapy and immunotherapy.
- To highlight the benefits of nanomedicine in addressing current therapeutic challenges.
Main Methods:
- Review of current literature on nanotechnology applications in oncology.
- Analysis of how nanomedicine addresses limitations in chemotherapy and immunotherapy.
- Illustrative examples of nanomedicine integration in cancer treatment.
Main Results:
- Nanomedicine demonstrates potential for enhanced precision in drug targeting.
- It offers protection against degradation for sensitive therapeutics like nucleic acids.
- Nanoparticles can improve gene delivery and mitigate immune-related adverse events.
Conclusions:
- Nanomedicine represents a powerful advancement in developing novel cancer treatment modalities.
- Integrating nanomedicine with chemotherapy and immunotherapy can significantly improve treatment efficacy and safety.
- Further research and application of cancer nanomedicine are crucial for optimizing tumor treatment.
