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Updated: Sep 18, 2025

Preclinical Assessment of the Bioactivity of the Anticancer Coumarin OT48 by Spheroids, Colony Formation Assays, and Zebrafish Xenografts
Published on: June 26, 2018
Osthole: A Coumarin with Dual Roles in Biology and Chemistry
Min Lv1,2, Haixia Ding2, Hui Xu1,2
1School of Marine Sciences, Ningbo University, Ningbo 315832, China.
Abstract:
Osthole is a natural coumarin-like compound isolated from the Fructus cnidii. In the last few years, this plant-derived product and its derivatives have aroused much attention for their interesting biological activities, including anticancer, anti-inflammatory, neuroprotective, and insecticidal effects. This review summarizes the recent progress on the biological activities of osthole and its derivatives from 2018 to early 2025, with a focus on their total synthesis, structural modifications, and mechanisms of action. Additionally, structure-activity relationships (SARs) of osthole derivatives are presented. This review aims to serve as a comprehensive reference for future research on osthole and its derivatives in both medicinal and agricultural applications.
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