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Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
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Related Experiment Video

Updated: Sep 18, 2025

Uptake of New Lipid-coated Nanoparticles Containing Falcarindiol by Human Mesenchymal Stem Cells
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Modified Lipid Particle Recognition: A Link Between Atherosclerosis and Cancer?

Amy E Hall1, Dhananjay Jade1,2, Faheem Shaik1,2

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Dysfunctional lipid metabolism links atherosclerosis and cancer. Targeting the LOX-1 scavenger receptor may offer new therapies for both arterial disease and cancers like prostate, colorectal, and lung cancer.

Keywords:
LOX-1apoptosisatherosclerosiscancerinflammationlipid particleproliferationscavenger receptorsignal transduction

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Area of Science:

  • Cardiovascular research
  • Oncology
  • Metabolic disease

Background:

  • Cardiovascular disease and cancer are leading causes of mortality worldwide.
  • Atherosclerosis, driven by lipid metabolism dysfunction, contributes to heart attacks and strokes.
  • Emerging evidence suggests a link between atherosclerosis and cancer development.

Purpose of the Study:

  • To review the emerging evidence connecting atherosclerosis and cancer.
  • To explore the role of scavenger receptors (SRs), particularly LOX-1, in mediating these links.
  • To discuss the therapeutic potential of targeting SR-mediated signaling.

Main Methods:

  • Literature review focusing on the role of lipid metabolism, scavenger receptors, and signaling pathways.
  • Analysis of evidence linking oxidized lipids, SRs (especially LOX-1), and cellular responses in both diseases.
  • Examination of the NF-κB pathway and LOX-1 signaling in atherosclerosis and cancer.

Main Results:

  • Modified and oxidized lipids in atherosclerosis activate scavenger receptors (SRs), promoting inflammation and plaque progression.
  • SR-mediated signaling, particularly via LOX-1, promotes cancer cell growth, proliferation, and metastasis.
  • LOX-1 signaling influences key cellular processes including apoptosis and epithelial-mesenchymal transition.
  • Elevated LOX-1 levels correlate with poor prognosis in cardiovascular disease and several cancers.

Conclusions:

  • The lectin-like oxidized low-density lipoprotein (LOX-1) scavenger receptor plays a dual role in atherosclerosis and cancer.
  • LOX-1 signaling pathways are implicated in the progression of both arterial disease and malignancies.
  • Inhibiting LOX-1 function presents a potential therapeutic strategy for managing both conditions.