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Related Concept Videos

Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

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Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
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Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

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Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
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Acute Kidney Injury III: Clinical Manifestations01:29

Acute Kidney Injury III: Clinical Manifestations

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Acute Kidney Injury (AKI) progresses through distinct clinical phases: the oliguric, diuretic, and recovery phases, each marked by unique manifestations and challenges.Oliguric Phase:The oliguric phase is the initial stage of AKI, typically lasting 10 to 14 days. This phase is marked by a significant reduction in urine output, usually less than 400 mL per day, indicating decreased kidney function. Fluid retention is a prominent feature, leading to symptoms such as edema, hypertension, and...
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Factors Affecting Renal Clearance: Renal Impairment01:17

Factors Affecting Renal Clearance: Renal Impairment

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Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
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Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

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Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
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Chronic Kidney Disease IV: Nursing Management01:18

Chronic Kidney Disease IV: Nursing Management

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Nursing management is essential for preventing complications, maintaining stability, and improving patients' quality of life in chronic kidney disease (CKD). By using a structured approach, nurses help slow CKD progression and support effective patient care​.1. Comprehensive patient assessmentEffective management begins with nurses reviewing the patient’s medical history, and identifying key risk factors like diabetes, hypertension, and nephrotoxic drug use. Nurses assess signs of...
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Renal Function in Chronic Hepatitis C Patients in Mongolia.

Gantogtokh Dashjamts1, Amin-Erdene Ganzorig1, Yumchinsuren Tsedendorj1

  • 1Department of Internal Medicine, Institute of Medical Sciences, Ministry of Economy and Development, Ulaanbaatar 14210, Mongolia.

Diagnostics (Basel, Switzerland)
|June 26, 2025
PubMed
Summary

Hepatitis C virus (HCV) infection significantly impairs kidney function, increasing the risk of reduced glomerular filtration rate. Factors like older age, obesity, and severe liver fibrosis worsen this decline.

Keywords:
chronic kidney diseaseextrahepatic manifestationglomerular filtration ratehepatitis C virus infectionliver fibrosis

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Area of Science:

  • Nephrology
  • Hepatology
  • Infectious Diseases

Background:

  • Hepatitis C virus (HCV) infection is prevalent in Mongolia (8.5%) and affects multiple organ systems beyond the liver.
  • Research indicates HCV infection can lead to systemic complications, including renal dysfunction.

Purpose of the Study:

  • To investigate the association between chronic Hepatitis C virus infection and renal dysfunction.
  • To evaluate the impact of HCV on kidney function parameters like glomerular filtration rate.

Main Methods:

  • A case-control study involving 111 patients with chronic HCV infection and 111 healthy controls.
  • Analysis of laboratory parameters and assessment of liver fibrosis scores.
  • Evaluation of renal function, specifically glomerular filtration rate.

Main Results:

  • HCV-infected patients showed a significantly lower glomerular filtration rate (105.3 ± 24.5) compared to controls (118.7 ± 18.5, p < 0.01).
  • Higher liver fibrosis scores were observed in the HCV group.
  • HCV infection increased the likelihood of decreased glomerular filtration rate by 25 times (OR 24.91, p = 0.002).

Conclusions:

  • Chronic Hepatitis C virus infection is a significant risk factor for kidney function loss.
  • Advanced age, obesity, and severe liver fibrosis are contributing factors to HCV-associated renal decline.