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Growth Assessment and Nutritional Status in Children with Congenital Adrenal Hyperplasia-A Cross-Sectional Study from

Thi Thuy Hong Nguyen1, Khanh Minh Le1, Thi Anh Thuong Tran1,2

  • 1Department of Paediatrics, Hanoi Medical University, Hanoi 11521, Vietnam.

Diagnostics (Basel, Switzerland)
|June 26, 2025
PubMed

Insights

Children with congenital adrenal hyperplasia (CAH) experience significant growth and nutritional issues, including stunting and vitamin D deficiency. Early intervention is key to managing these complex health challenges in pediatric patients.

Area of Science:

  • Pediatric Endocrinology
  • Metabolic Disorders
  • Nutritional Science

Background:

  • Congenital adrenal hyperplasia (CAH) poses risks for impaired growth and metabolic disturbances in children.
  • Standard glucocorticoid therapy may not fully address these complications.
  • Vietnamese children with CAH require focused evaluation for growth and nutritional status.

Purpose of the Study:

  • To assess growth outcomes, nutritional status, and associated factors in children with CAH.
  • To identify clinical, biochemical, and treatment-related factors influencing health in pediatric CAH patients.
  • To provide data for optimizing management strategies in a Vietnamese tertiary pediatric center.

Main Methods:

  • Cross-sectional study of 201 children (1.1-16.5 years) with CAH.
  • Evaluation of anthropometric parameters, WHO growth standards, and bone age (radiographic assessment).
  • Assessment of biochemical markers (calcium, phosphate, 25-hydroxyvitamin D) and clinical features.

Main Results:

  • Stunting affected 16.4%, while 53.3% were overweight/obese.
  • Bone age advancement occurred in 51.7%; 85.6% had vitamin D insufficiency/deficiency; 85.1% had hypocalcemia.
  • Risk factors for adverse outcomes included older age, prolonged corticosteroid use, high androgens, and treatment imbalance.

Conclusions:

  • Growth impairment, nutritional deficiencies, and skeletal maturation issues are common in Vietnamese children with CAH.
  • Identifying risk factors and implementing tailored endocrine and nutritional management are vital.
  • Optimizing long-term outcomes requires a comprehensive approach to pediatric CAH care.

Keywords:
CAHVietnamese childrenbone agecalcium deficiencycongenital adrenal hyperplasiaglucocorticoid treatmentgrowthobesityvitamin D deficiency

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