MCM4 as Potential Metastatic Biomarker in Lung Adenocarcinoma
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View abstract on PubMed
Summary
This summary is machine-generated.Minichromosome maintenance 4 (MCM4) is a potential biomarker for lung adenocarcinoma metastasis. This study identified MCM4 as a key gene associated with poor prognosis and tumor invasiveness in LUAD patients.
Area Of Science
- Oncology
- Molecular Biology
- Genomics
Background
- Lung adenocarcinoma (LUAD) is a major cause of cancer mortality, often diagnosed at advanced, metastatic stages.
- Identifying biomarkers for LUAD metastasis is crucial for early diagnosis and effective therapeutic strategies.
Purpose Of The Study
- To identify key genes associated with metastasis in LUAD.
- To evaluate the prognostic and diagnostic potential of identified genes in LUAD.
Main Methods
- Analysis of four Gene Expression Omnibus (GEO) datasets and The Cancer Genome Atlas (TCGA) data for differentially expressed genes (DEGs) in LUAD.
- Functional enrichment analysis (Gene Ontology, KEGG) and network analysis (Cytoscape) to identify hub genes.
- Validation of hub gene expression, prognostic value (Kaplan-Meier plotter), and clinical correlation using multiple databases.
Main Results
- 333 DEGs were identified, enriched in metastasis-related pathways like angiogenesis and immune escape.
- Ten hub genes were identified, with MCM4 showing significant upregulation in LUAD.
- MCM4 expression correlated with poor overall survival, post-progression survival, invasiveness markers, and matrix metalloproteinases.
Conclusions
- MCM4 is a novel potential biomarker for LUAD metastasis and prognosis.
- MCM4's consistent overexpression and association with metastatic features suggest its utility as a diagnostic or therapeutic target in advanced LUAD.
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