Related Experiment Video

Updated: Sep 18, 2025

Detection of Small GTPase Prenylation and GTP Binding Using Membrane Fractionation and GTPase-linked Immunosorbent Assay
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Detection of Small GTPase Prenylation and GTP Binding Using Membrane Fractionation and GTPase-linked Immunosorbent Assay

Published on: November 11, 2018

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Multifaceted Roles of Guanylate-Binding Proteins in Cancer

Derin Ahmetoglu1, Haoyi Zheng2, Aaron Swart2

  • 1Brain Tumor Research Centre of Excellence, Peninsula Medical School, University of Plymouth, Plymouth PL6 8BU, UK.

International Journal of Molecular Sciences
|June 26, 2025
PubMed

Insights

Guanylate-binding proteins (GBPs) are crucial for immunity against pathogens. This review explores their dual role in cancer, impacting tumor growth and treatment, offering new therapeutic strategies.

Area of Science:

  • Immunology
  • Molecular Biology
  • Oncology

Background:

  • Guanylate-binding proteins (GBPs) are interferon-inducible GTPases vital for innate immunity against intracellular pathogens.
  • GBPs recognize pathogen- and danger-associated molecular patterns, mediating lysosomal targeting, inflammation, and apoptosis.
  • Their roles extend to cancer, where they can promote or suppress tumor progression depending on the context.

Purpose of the Study:

  • To comprehensively review the structural features, immune functions, and cancer-related roles of human GBPs.
  • To elucidate the molecular mechanisms underlying GBP involvement in malignancy.
  • To explore the prognostic and therapeutic potential of targeting GBPs in cancer treatment.

Main Methods:

  • Literature review of existing research on guanylate-binding proteins.
  • Analysis of structural, functional, and clinical data related to GBPs in immunity and cancer.
  • Synthesis of current insights into GBP mechanisms and therapeutic implications.

Main Results:

  • GBPs are key effectors in cell-autonomous immunity against diverse pathogens.
  • GBPs exhibit context-dependent functions in cancer, influencing immune signaling, apoptosis, and therapy resistance.
  • Specific GBP roles vary across different tumor types, affecting malignancy or suppression.

Conclusions:

  • Understanding the complex roles of GBPs in cancer is critical for developing novel therapeutic strategies.
  • Targeting GBP regulation may offer new avenues for cancer treatment by modulating anti-tumor immunity or overcoming resistance.
  • Further research into GBP mechanisms can refine their prognostic value and clinical applications.
Keywords:
GTPasecancerguanylate-binding proteinsimmunity

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