Related Experiment Video

Updated: Sep 18, 2025

Comparing Metastatic Clear Cell Renal Cell Carcinoma Model Established in Mouse Kidney and on Chicken Chorioallantoic Membrane
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Comparing Metastatic Clear Cell Renal Cell Carcinoma Model Established in Mouse Kidney and on Chicken Chorioallantoic Membrane

Published on: February 8, 2020

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Sodium-Glucose Cotransporter 2 and Glucose Levels Affect Clear Cell Renal Cell Carcinoma Progression

Yujiro Nagata1, Ikko Tomisaki1, Hisami Aono1

  • 1Department of Urology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu 807-8555, Japan.

International Journal of Molecular Sciences
|June 26, 2025
PubMed

Insights

Sodium-glucose cotransporter 2 (SGLT2) inhibition significantly reduced clear cell renal cell carcinoma (ccRCC) progression and enhanced apoptosis. SGLT2 inhibitors may offer novel therapeutic potential for ccRCC patients, especially those with diabetes.

Area of Science:

  • Oncology
  • Nephrology
  • Endocrinology

Background:

  • The role of sodium-glucose cotransporter 2 (SGLT2) in clear cell renal cell carcinoma (ccRCC) progression remains unclear.
  • Understanding SGLT2's biological significance is crucial for identifying new therapeutic targets in ccRCC.

Purpose of the Study:

  • To investigate the role of SGLT2 in ccRCC tumor progression.
  • To evaluate the efficacy of SGLT2 inhibition on ccRCC cell proliferation, migration, and apoptosis.

Main Methods:

  • Utilized the KMRC-1 ccRCC cell line with a VHL gene mutation.
  • Assessed the effects of the SGLT2 inhibitor dapagliflozin and SGLT2 knockdown on ccRCC cells under varying glucose concentrations.
  • Measured cell viability, migration, colony formation, and apoptosis.

Main Results:

  • Dapagliflozin significantly reduced ccRCC cell proliferation and migration, particularly in high glucose conditions (25 mM).
  • SGLT2 knockdown also decreased cell viability, migration, and colony formation.
  • SGLT2 inhibition demonstrated efficacy in both normoglycemic (5 mM) and severe hyperglycemia (25 mM) models, enhancing apoptosis.

Conclusions:

  • SGLT2 plays a significant role in the progression of ccRCC with VHL mutations.
  • SGLT2 inhibitors show promise as a novel therapeutic strategy for ccRCC, especially in patients with concurrent diabetes mellitus.
Keywords:
SGLT2clear cell renal cell carcinomaglucosetumor progressionvon Hippel–Lindau gene

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