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Related Experiment Video

Updated: Sep 18, 2025

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Montelukast Improves Urinary Bladder Function After Complete Spinal Cord Injury in Rats.

Elena E Keller1, Sophina Bauer2, Karin Roider1

  • 1Institute of Molecular and Regenerative Medicine, Paracelsus Medical University, Strubergasse 21, 5020 Salzburg, Austria.

International Journal of Molecular Sciences
|June 26, 2025
PubMed
Summary
This summary is machine-generated.

Early montelukast (MLK) treatment in rats with spinal cord injury (SCI) preserved bladder function. This pilot study suggests MLK may improve lower urinary tract (LUT) integrity after SCI.

Keywords:
detrusor sphincter dyssynergiainflammationleukotrieneratspinal cord injuryurinary bladder

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Area of Science:

  • Neuroscience
  • Urology
  • Pharmacology

Background:

  • Spinal cord injury (SCI) frequently causes severe bladder dysfunction, impacting quality of life.
  • Neuroinflammation in the lower urinary tract (LUT) is a suspected driver of neurogenic bladder dysfunction and fibrosis post-SCI.
  • Leukotrienes are potent inflammatory mediators implicated in SCI-related LUT pathology.

Purpose of the Study:

  • To investigate the therapeutic potential of early montelukast (MLK) administration.
  • To assess MLK's effects on LUT function and structure following severe SCI in a rat model.
  • To determine if MLK can mitigate SCI-induced bladder dysfunction.

Main Methods:

  • Lewis rats (female, n=50) underwent T9 spinal cord transection and received a bladder catheter.
  • Daily oral montelukast (MLK) treatment commenced on day one post-injury.
  • Bladder and locomotor function were monitored, with subsequent histological and immunohistochemical analysis of bladder tissue.

Main Results:

  • Clinically relevant MLK concentrations were achieved in plasma and cerebrospinal fluid post-SCI.
  • Montelukast administration significantly improved bladder functionality in SCI rats.
  • No significant impact of MLK on smooth muscle alignment or uroepithelial integrity was observed at this early time point.

Conclusions:

  • Early, continuous oral MLK treatment shows promise in preserving LUT function after SCI.
  • This pilot study provides initial evidence for MLK's potential in improving tissue integrity post-SCI.
  • Further research is warranted to explore the long-term effects and mechanisms of MLK in SCI-related bladder dysfunction.