Pathological Alterations in Human Blood Microbiome-An Updated Review

Area of Science:

• Microbiology
• Human Health
• Disease Biomarkers

Background:

• The blood microbiome, originating from oral and intestinal microflora, is dynamic.
• Significant alterations in the blood microbiome are observed during various pathological conditions.

Purpose of the Study:

• To review and summarize studies on the human blood microbiome in relation to nervous system, cardiovascular, respiratory, liver, kidney, and metabolic disorders.
• To demonstrate links between blood microbiome composition and these diseases.

Main Methods:

• Literature review of studies investigating the human blood microbiome.
• Analysis of microbial signatures across different disease categories.

Main Results:

• Analogous alterations in blood microbiome composition are noted across diverse diseases.
• Specific microbial signatures are associated with particular conditions, e.g., elevated Proteobacteria in cardiovascular, renal, and metabolic disorders.
• Bacteroidetes are prevalent in respiratory and liver diseases, with specific genera like Flavobacterium and Enterobacteriaceae linked to respiratory and liver ailments, respectively.

Conclusions:

• The human blood microbiome composition exhibits disease-specific alterations.
• The blood microbiome holds potential as a biomarker for diagnosing and monitoring certain diseases.