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Quantitative Ultrasound Characterization of Intensity-Dependent Changes in Muscle Tissue During Percutaneous
Miguel Malo-Urriés1,2, Jacobo Rodríguez-Sanz3,4, Sergio Borrella-Andrés1
1Healh Sciences Faculty, Department of Physiotry and Nursing, University of Zaragoza, 50009 Zaragoza, Spain.
Journal of Clinical Medicine
|June 26, 2025
Summary
Percutaneous electrolysis, a galvanic current therapy, shows dose-dependent structural changes in muscle tissue. Quantitative ultrasound can guide optimal treatment dosage for personalized physical therapy.
Area of Science:
- Physiotherapy
- Biomedical Engineering
- Musculoskeletal Research
Background:
- Percutaneous electrolysis uses galvanic current for musculoskeletal tissue changes.
- Optimal dosage for muscle tissue application is not well-defined.
- This study investigates galvanic current effects on muscle tissue.
Purpose of the Study:
- Evaluate dose-dependent effects of galvanic current on cadaveric muscle.
- Utilize quantitative ultrasound analysis for objective biomarker identification.
- Guide optimal galvanic current dosage for percutaneous electrolysis treatments.
Main Methods:
- Applied varying galvanic current intensities (0-10.0 mA) to 29 cadaveric medial gastrocnemius samples.
- Measured quantitative ultrasound parameters (geometric, textural features).
- Performed correlation and regression analyses, and statistical comparisons across dose groups.
Main Results:
- Significant dose-response relationships found in ultrasound parameters (A_Number, A_Area, A_Perimeter, A_Contrast).
- A predictive variable, Muscle_Electrolysis_Dose, explained 66.7% of dose variance.
- Significant differences observed between low, medium, and high galvanic current dose groups.
Conclusions:
- Quantitative ultrasound effectively detects structural changes from percutaneous electrolysis in muscle.
- Results support objective, image-based criteria for optimizing galvanic current dosage.
- Enhances precision and personalization of physical therapy treatments.

