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Updated: Jun 25, 2026

Screening for Amyloid Aggregation by Semi-Denaturing Detergent-Agarose Gel Electrophoresis
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Screening for Systemic Light-Chain Amyloidosis in Patients Over 60 with λ Monoclonal Gammopathies

Ping Zhou1, Mahesh M Mansukhani2, Raymond Yeh2

  • 1The Tufts Medicine Myeloma and Amyloid Program, Tufts Medical Center, 800 Washington Street, P.O. Box 826, Boston, MA 02111, USA.

Journal of Clinical Medicine
|June 26, 2025
PubMed
Summary

Early diagnosis of light-chain amyloidosis (AL) is crucial. A study identified AL-related genes and cytogenetic abnormalities in smoldering myeloma (SMM) and monoclonal gammopathy of undetermined significance (MGUS) patients, aiding earlier AL detection.

Keywords:
AL amyloidosisscreeningsmoldering myeloma

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