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Related Concept Videos

Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

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In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
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Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

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Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
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Glaucoma: Overview01:25

Glaucoma: Overview

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Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
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Related Experiment Video

Updated: Sep 18, 2025

Regenerative Therapy by Suprachoroidal Cell Autograft in Dry Age-related Macular Degeneration: Preliminary In Vivo Report
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Laser Prophylaxis for Dry Age-Related Macular Degeneration: Current Evidence.

Jeffrey K Luttrull1,2, Stephen H Sinclair2,3, Igor Kozak2,4

  • 1Ventura County Retina Vitreous Medical Group, 3160 Telegraph Rd., Suite 230, Ventura, CA 93003, USA.

Journal of Clinical Medicine
|June 26, 2025
PubMed
Summary

Prophylactic laser treatment for dry age-related macular degeneration (AMD) shows promise. Avoiding laser-induced retinal damage (LIRD) may prevent vision loss and slow disease progression in high-risk eyes.

Keywords:
age-related macular degenerationlaserneovascularizationpreventionpropensity scorereal-world data

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Area of Science:

  • Ophthalmology
  • Retinal Diseases
  • Medical Interventions

Background:

  • Age-related macular degeneration (AMD) is a primary cause of irreversible vision loss globally.
  • Non-exudative (dry) AMD affects a significant population, with high-risk individuals facing accelerated progression.
  • Understanding effective prophylactic treatments is crucial for preserving vision.

Purpose of the Study:

  • To review the current evidence on the role of prophylactic panmacular laser treatment for age-related macular degeneration (AMD).
  • To evaluate the safety and efficacy of laser interventions in preventing vision loss in dry AMD.

Main Methods:

  • A narrative review of studies was conducted.
  • Literature search focused on PubMed for studies involving laser treatment in dry AMD.
  • Analysis included both randomized and real-world data (RWD) clinical studies.

Main Results:

  • Laser treatment causing laser-induced retinal damage (LIRD) showed no benefit or accelerated vision loss in dry AMD, especially in high-risk eyes.
  • Studies avoiding LIRD suggest laser treatment can be safe and effective in slowing progression and preventing neovascularization.
  • The highest-risk eyes appeared to benefit most from LIRD-avoiding laser interventions.

Conclusions:

  • Prophylactic laser treatment for dry AMD presents a promising strategy for preventing age-related vision loss.
  • Further prospective clinical trials are necessary to confirm these findings.
  • If confirmed, laser prophylaxis could become a leading, cost-effective approach to reducing vision loss from AMD.