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Research Domains Biomedical and Clinical Sciences Oncology and Carcinogenesis Predictive and prognostic markers
Research Domains
Biomedical and Clinical Sciences
Oncology and Carcinogenesis
Predictive and prognostic markers
Vitacrystallography: Appearance and Development of Cancer-Induced Structural Biomarkers in a Mouse Model

Vitacrystallography: Appearance and Development of Cancer-Induced Structural Biomarkers in a Mouse Model

Oleksii Avdieiev ¹, Sergey A Denisov ^1,2, Ashkan Ajeer ³, Lois Adams ³, Charlene Greenwood ³, Heather Nesbitt ⁴, Keith Thomas ⁵, Keith Rogers ^1,6, Olga Solovyeva ¹, Lev Mourokh ^1,7, Pavel Lazarev ¹

Oleksii Avdieiev ¹, Sergey A Denisov ^1,2, Ashkan Ajeer ³

¹EosDx UK Ltd., 5 New Street Square, London EC4A 3TW, UK.
²Institut de Chimie Physique, UMR8000, CNRS, Université Paris-Saclay, Bât. 349, 91405 Orsay, France.
³School of Chemical and Physical Sciences, Keele University, Keele ST5 5BG, UK.
⁴School of Pharmacy and Pharmaceutical Sciences, Ulster University, Coleraine BT52 1SA, Co. Londonderry, Northern Ireland, UK.
⁵School of Biomedical Sciences, Ulster University, Coleraine BT52 1SA, Co. Londonderry, Northern Ireland, UK.
⁶Shrivenham Campus, Cranfield University, Swindon SN6 8LA, UK.
⁷Physics Department, Queens College, City University of New York, 65-30 Kissena Blvd, Flushing, NY 11367, USA.

⁰EosDx UK Ltd., 5 New Street Square, London EC4A 3TW, UK.

Life (basel, Switzerland) +

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June 26, 2025

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June 26, 2025

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View abstract on PubMed

Summary

This summary is machine-generated.

Researchers discovered a new structural biomarker for prostate cancer using X-ray scattering. This biomarker, based on lipid and water ratios, tracks cancer progression and can aid in early disease detection and monitoring treatment effectiveness.

Area Of Science

Biophysics
Medical Imaging
Oncology

Background

Conventional diagnostics for diseases like prostate cancer can be complemented by structural biomarkers.
X-ray scattering offers a method for identifying these biomarkers within tissues.

Purpose Of The Study

To investigate the potential of X-ray scattering for detecting and monitoring prostate cancer progression.
To identify a novel structural biomarker for prostate cancer in mouse models.

Main Methods

Prostate cancer was induced in mouse models, with one lobe inoculated and the other left as a control.
Tissue samples were collected at various time points and analyzed using X-ray scattering.
Structural changes were assessed by examining the ratio of X-ray scattering peaks related to lipids and water.

Main Results

A distinct ratio between X-ray scattering peaks for lipids and water was identified as a structural biomarker for prostate cancer.
This biomarker demonstrated a developmental trajectory that correlated with tumor advancement.
The biomarker's progression along its trajectory indicated disease progression or healing.

Conclusions

The lipid-to-water X-ray scattering ratio serves as a viable structural biomarker for prostate cancer.
This biomarker can be used to establish a baseline for disease staging and monitor treatment efficacy.
X-ray scattering analysis provides a pathway for early disease detection and personalized patient management.

Keywords:

X-ray scattering cancer trajectory mouse model prostate cancer structural biomarkers vitacrystallography

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Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...

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