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Adapting Human Videofluoroscopic Swallow Study Methods to Detect and Characterize Dysphagia in Murine Disease Models
Published on: March 1, 2015
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Research advances in dysphagia animal models
Junhui Bai1, Keling Cheng1, Nannan Zhang1,2
1Department of Rehabilitation, the First Affiliated Hospital, Fujian Medical University, Fuzhou, China.
Animal Models and Experimental Medicine
|June 26, 2025
Summary
This review summarizes animal models for dysphagia, a common complication of stroke, Parkinson's disease (PD), and amyotrophic lateral sclerosis (ALS). It provides a guide for selecting appropriate models to study these conditions.
Area of Science:
- Neuroscience
- Gastroenterology
- Comparative Medicine
Background:
- Dysphagia is a frequent complication following stroke, Parkinson's disease (PD), and amyotrophic lateral sclerosis (ALS).
- Understanding the pathogenesis and treatment of dysphagia necessitates reliable animal models.
- Current models primarily utilize rodents, nonhuman primates, pigs, and dogs.
Purpose of the Study:
- To systematically review the establishment and evaluation of dysphagia animal models.
- To focus on models relevant to stroke, PD, and ALS.
- To provide a basis for selecting suitable animal models for dysphagia research.
Main Methods:
- Systematic literature review.
- Analysis of methods for establishing dysphagia models in different animal species.
- Evaluation of the suitability of these models for studying stroke, PD, and ALS.
Main Results:
- Summary of established dysphagia models in rodents, nonhuman primates, pigs, and dogs.
- Assessment of the strengths and limitations of each model type.
- Identification of models commonly used for stroke, PD, and ALS-related dysphagia.
Conclusions:
- The choice of animal model is crucial for advancing dysphagia research in neurological diseases.
- This review offers a framework for researchers to select appropriate models.
- Further refinement of animal models can improve the translation of research findings to clinical practice.
