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Comparative Risk of Developing Interstitial Cystitis With Childhood Gastrointestinal, Urological, Autoimmune, or
Mohammad Alipour-Vaezi1, Robert S McNamara2, Margaret R Rukstalis2
1Grado Department of Industrial & Systems Engineering, Virginia Tech, Blacksburg, Virginia, USA.
Neurourology and Urodynamics
|June 26, 2025
Summary
Childhood gastrointestinal and urological conditions are linked to adult interstitial cystitis (IC) risk. Early identification of these conditions can aid in preventing IC and managing its impact.
Area of Science:
- Urology
- Gastroenterology
- Epidemiology
Background:
- Interstitial cystitis (IC) is a chronic condition with unclear etiology.
- Early-life conditions like gastrointestinal (GI) disorders, urological anomalies (UA), psychiatric disorders (PD), and autoimmune diseases (AD) are potential risk factors for adult IC.
- This study investigates these associations using a large retrospective cohort.
Purpose of the Study:
- To examine the association between childhood GI and UA conditions and the development of adult IC.
- To identify potential early risk factors for interstitial cystitis.
- To inform targeted early interventions and preventative care strategies for IC.
Main Methods:
- Retrospective cohort analysis of over 118 million patient records from the TriNetX US Collaborative Network.
- Comparison of IC incidence over 14 years between study and control groups based on childhood disorders.
- Statistical analysis using propensity score matching and Kaplan-Meier survival analysis.
Main Results:
- Childhood GI and UA conditions significantly increase adult IC risk.
- Irritable bowel syndrome (IBS) showed a risk ratio of 2.9 for IC.
- Urinary tract infections (UTIs) showed a risk ratio of 3.2 for IC.
- Females exhibited higher incidences of UA and AD during adolescence.
- Individuals with early-life conditions had a higher prevalence of comorbidities.
Conclusions:
- Childhood GI and UA conditions are significant predictive markers for adult IC.
- Early detection and intervention in at-risk populations can mitigate the long-term burden of IC.
- Findings highlight the complex interplay of early health factors in IC pathogenesis.
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