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Related Concept Videos

Epilepsy and Seizures: Overview01:24

Epilepsy and Seizures: Overview

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Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
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Psychosis and Antipsychotic Drugs: Overview01:28

Psychosis and Antipsychotic Drugs: Overview

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The term "psychosis" refers to a spectrum of mental disorders characterized by abnormal thoughts, perceptions, and behaviors. It can manifest as mood disorders, dementia, delirium with psychotic features, substance-induced psychosis with psychotic features, brief psychotic disorder, delusional disorder, schizoaffective disorder, and schizophrenia. Among all these disorders, schizophrenia is the most common psychotic disorder, affecting 1% of the worldwide population. Psychotic...
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Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders01:27

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders

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Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
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Psychosis: Goals of Pharmacotherapy01:26

Psychosis: Goals of Pharmacotherapy

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Antipsychotic drugs are a crucial treatment method for acute and chronic psychoses, bipolar illness, and behavioral disorders. The selection of these drugs depends on several factors, including the state of the disease, clinical judgment, possible drug interactions, and the patient's sensitivity to adverse effects. In immediate scenarios, such as delirium and dementia, short-term treatment with low doses of high-potency typical or atypical agents can effectively manage symptom exacerbation.
214
Seizures: Classification01:13

Seizures: Classification

612
Epilepsy is primarily characterized by unpredictable seizures, either provoked by an identifiable factor, such as injury or illness, or unprovoked, occurring spontaneously without apparent cause.
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
612
Antiepileptic Drugs: GABAergic Pathway Potentiators01:18

Antiepileptic Drugs: GABAergic Pathway Potentiators

681
γ-aminobutyric acid or GABA, plays a pivotal role as an inhibitory neurotransmitter in the brain. GABA pathway potentiators, also known as GABAergic drugs, are a class of pharmaceutical agents designed to enhance the functioning of the GABAergic system. These medications primarily treat epilepsy, a neurological disorder characterized by recurrent seizures.
The key GABA pathway potentiators used in epilepsy management are as follows.
Benzodiazepines are a well-known class of drugs used for...
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Related Experiment Video

Updated: Sep 18, 2025

Electrophoretic Delivery of γ-aminobutyric Acid GABA into Epileptic Focus Prevents Seizures in Mice
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Epilepsy and psychosis: navigating through a complex intersection.

Marco Mula1,2, Andres M Kanner3, Allan H Young4,5

  • 1Department of Neurology, St George's University Hospital, London, UK.

Bjpsych Open
|June 26, 2025
PubMed
Summary
This summary is machine-generated.

Epilepsy and psychosis have a bidirectional relationship. This review explores managing psychotic symptoms in epilepsy, noting the lack of specific guidelines but suggesting adapted psychosis treatment strategies.

Keywords:
Epilepsyantipsychotic drugsantiseizure drugslurasidonepsychosis

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Area of Science:

  • Neurology
  • Psychiatry
  • Clinical Neuroscience

Background:

  • High comorbidity of psychiatric disorders in epilepsy (up to 43%).
  • Psychoses represent a severe comorbidity in epilepsy patients.
  • Understanding the epilepsy-psychosis link is crucial for patient care.

Purpose of the Study:

  • To review the interplay between epilepsy and psychosis.
  • To identify diagnostic and management challenges of psychotic symptoms in epilepsy.
  • Focus on literature from the past 10 years.

Main Methods:

  • Narrative review of articles.
  • PubMed database search from June 2014 to December 2024.
  • Keywords: psychosis, seizure, epilepsy, convulsion.

Main Results:

  • Bidirectional association: psychosis increases epilepsy risk, and vice versa.
  • Psychotic symptoms in epilepsy can be seizure-related, treatment-related, or independent.
  • Clinical presentation and management differ based on the scenario.

Conclusions:

  • No specific guidelines exist for managing psychosis in epilepsy.
  • Existing psychosis treatment policies can be adapted.
  • Management requires consideration of epilepsy-specific needs and peculiarities.