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Updated: Sep 18, 2025

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease
Published on: April 28, 2019
Expanded dengue syndrome complicated by fulminant liver failure and prolonged intrahepatic cholestasis
Pothumarthy Swathi Kiran1, Praveen Kumar Tirlangi2, Kavitha Saravu3
1Senior Resident, Department of Infectious Diseases, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, India.
Abstract:
We report a case of expanded dengue syndrome in a 38-year old man who developed fulminant liver failure and prolonged intrahepatic cholestasis. Initially presenting with fever, weakness, and jaundice, he was diagnosed with dengue by positive NS1 antigen, polymerase chain reaction, and Immunoglobulin M tests. Despite supportive care, the patient progressed to severe hepatic encephalopathy and coagulopathy ensued. Management included N-acetylcysteine infusion, thromboelastography-guided transfusions and sedation with propofol. Persistent cholestatic jaundice was managed with ursodeoxycholic acid. The patient's condition gradually improved, highlighting the importance of tailored interventions for severe dengue liver complications.
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